Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing |
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| Authors: | Singh Subhash Soe Soe Roussilhon Christian Corradin Giampietro Druilhe Pierre |
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| Affiliation: | Bio-medical Parasitology Unit, Institute Pasteur, 28 rue du Dr Roux, 75015 Paris, France. |
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| Abstract: | Plasmodium falciparum MSP6 is a merozoite surface antigen that shows organization and sequence homologies similar to those of MSP3. Within its C-terminus conserved region, it presents some epitopes that are cross-reactive with MSP3 and others that are not, both being targets of naturally occurring antibodies that block the P. falciparum erythrocytic cycle in cooperation with monocytes. |
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