| Clotting mechanism in beagles irradiated by 4.5 Gy γ-rays |
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| 作者姓名： | 赵振虎 王宁 李明 邢爽 黄海潇 欧红玲 熊国林 赵燕芳 谢玲 王金香 缪竞诚 朱南康 张学光 罗庆良 从玉文 |
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| 作者单位： | 军事医学科学院放射与辐射医学研究所,北京,100850;第二炮兵总医院;苏州大学医学部; |
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| 基金项目： | 国防科工委"十一五"核科学基础研究重点项目 |
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| 摘 要： | Objective To explore the clotting mechanism in beagles irradiated by 4.5 Gy γ-rays after treatment with supportive care,or supportive care and combined cytokines.Methods Sixteen beagles were divided into irradiation control group,Supportive care group and combined cytokines treatment group.Platelet aggregation test,thrombelagtography (TEG) and the time measurement were analyzed in vitro.Results In irradiation group and supportive care group,the platelet aggregation rates in beagles were decreased markedly and the k value of TEG was increased 7 d post-irradiation,while those indexes in combined cytokines treatment group changed little.At 14 d post-irradiation,each parameter of TEG in irradiated group changed obviously.The values of r,k,r+k and M were elevated significantly,clotting time and the maximum coagulation time of thrombus delayed,the Ma value was decreased markedly,and the maximum elasticity amplitude of thrombus was diminished.All parameters in combined cytokines treatment group were better than those in supportive care group.The thrombin time was prolonged obviously in irradiated group 14 d post-irradiation,while the thrombin time was the longest at 2-3 weeks post irradiation in supportive care group and combined cytokines treatment group(P>0.05).Conclusions Cytokines could improve the platelet aggregation and the blood clotting functions of beagles suffering from acute radiation sickness.
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| 关 键 词： | 血栓弹力图 血小板聚集率 凝血 细胞因子 |
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