| 铜摄入量对大鼠动脉粥样硬化炎症因子影响 |
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| 引用本文： | 段链, 张明, 金银龙. 铜摄入量对大鼠动脉粥样硬化炎症因子影响[J]. 中国公共卫生, 2010, 26(8): 1021-1022. DOI: 10.11847/zgggws2010-26-08-43 |
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| 作者姓名： | 段链 张明 金银龙 |
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| 作者单位： | 1.中国疾病预防控制中心环境与健康相关产品安全所, 北京100021 |
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| 摘 要： | 目的 探讨铜摄入量对大鼠动脉粥样硬化(arteriosclerosis,AS)相关炎症因子的影响。方法 选择Wistar大鼠饲以缺铜饲料并给予不同剂量葡萄糖酸铜30 d,以大鼠血中铜蓝蛋白(CP)为铜摄入量评价指标,分析其对大鼠AS相关炎症因子的影响。结果 大鼠血中CP活力为20.442～37.569 U/L时,C反应蛋白(CRP)可对铜摄入量过高或过低引发的AS作出预警;铜摄入量低于或高于日常摄入量时,同型半胱氨酸(HCY)水平均高于对照组(P<0.05);CP活力超出30.279～37.569 U/L时,各组细胞间粘附因子-1(ICAM-1)水平均明显高于正常对照组(P<0.05);CP活力超出20.442～37.569 U/L时,各组单核细胞趋化因子-1(MCP-1)水平均高于正常对照组(P<0.05)。结论 铜摄入量过高或过低均可不同程度激活AS相关各炎症因子,有引起AS的潜在风险。
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| 关 键 词： | 铜 铜蓝蛋白 动脉粥样硬化 炎症因子 |
| 收稿时间： | 2009-11-25 |
Effect of copper intake on inflammatory factors associated with arteriosclerosis in rats |
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| DUAN Lian, ZHANG Ming, JIN Yin-long. Effect of copper intake on inflammatory factors associated with arteriosclerosis in rats[J]. Chinese Journal of Public Health, 2010, 26(8): 1021-1022. DOI: 10.11847/zgggws2010-26-08-43 |
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| Authors: | DUAN Lian ZHANG Ming JIN Yin-long |
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| Affiliation: | 1.Institute of Environmental Health and Related Product Safety, China Centers for Disease Control and Prevention, Beijing 100021, China |
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| Abstract: | Objective To find out the effect of copperintake on the inflammatory factors a ssociated with arteriosclerosis(AS)formation in rats.Methods Wistar rats were fed with special feed without copper,and stock diet was given with copper gluconate at different dose with stomach tube every day for 30 days.Cerulopla smin(CP)was used to study the effect of copper on the inflammatory factors associated with AS formation.Results When the activity of CP was in the range of 20.442-37.5692U/L,the Creactive prote in(CRP)could predict AS caused by abnormal copper intake.When the copper intake of the rats was lower or higher than normal daily in take,the level of homocy steine(HCY)in the blood of the rats was higher than normal level(P<0.05).The in tercellular adhesion molecule-1(ICAM-1)level was higher than the normal level in the rats with abnormal copper intake with significant difference(P<0.05)when the activity of CP was in the range of 30.279-37.569U/L.The monocyte chemotactic factor-1(MCP-1)level was higher than the normal level in all groups with a significant difference(P<0.05)when the activity of CP was in the range of 20.442-37.569U/L.Conclusion The inflammatory factors associated with AS could be activated when the copper in take of rats were extremely highorlow than the normal level. |
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| Keywords: | copper ceruloplasmin athero sclerosis inflammatory factor |
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