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Adenosine Deaminase Deficiency and Purine Nucleoside Phosphorylase Deficiency in Common Variable Immunodeficiency |
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| Authors: | Amy Fleischman Michael S. Hershfield Stephan Toutain Howard M. Lederman Kathleen E. Sullivan Mary Beth Fasano Jeff Greene Jerry A. Winkelstein |
| Affiliation: | Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland1.; Department of Medicine, The Duke University School of Medicine, Durham, North Carolina2.; and Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania3.; and Department of Medicine, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina4. |
| Abstract: | The clinical presentations of adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency are widely variable and include clinical and immunologic findings compatible with common variable immunodeficiency. The screening of 44 patients with common variable immunodeficiency failed to identify any individuals with deficiencies of these enzymes. |
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