In vivo resistance of a laboratory-selected Aspergillus fumigatus isolate to amphotericin B |
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| Authors: | Manavathu Elias K Cutright Jessica L Chandrasekar Pranatharthi H |
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| Affiliation: | Department of Internal Medicine, 427 Lande Building, Wayne State University, 550 E. Canfield, Detroit, MI 48201, USA. aa1388@wayne.edu |
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| Abstract: | The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model. |
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