Extranodal NK/T‐cell lymphoma,nasal type of the uterine cervix: A case report |
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| Authors: | Makiko Omori M.D. Ph.D. Naoki Oishi M.D. Ph.D. Tadao Nakazawa M.D. Ph.D. Kumiko Nakazawa C.T. I.A.C. Ph.D. Toru Mitsumori M.D. Ph.D. Tsutomu Yuminamochi C.T. I.A.C. Keita Kirito M.D. Ph.D. Shuji Hirata M.D. Ph.D. |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, University of Yamanashi, Yamanashi, Japan;2. Department of Pathology, University of Yamanashi, Yamanashi, Japan;3. Department of Hematology/Oncology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan |
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| Abstract: | We report a rare case of extranodal NK/T‐cell lymphoma, nasal type of the uterine cervix that showed cytologic features mimicking cervical cancer. A 65‐year‐old woman presented with vaginal bleeding. Gynecological examination revealed a bulky tumor of the cervix. A conventional Papanicolaou‐stained cervical smear showed hypercellularity consisting of numerous variably sized cohesive clusters that mimicked epithelial tumors, with a necrotic and inflammatory background. A small number of individually scattered cells were also identified. These scattered cells showed pleomorphic, often cleaved, or horseshoe‐shaped nuclei and pale cytoplasm. Biopsy specimens revealed a diffuse growth of atypical cells with an angiocentric pattern. Extensive necrosis and infiltration of inflammatory cells were present. There were numerous mitotic figures. The tumor cells were positive for CD45RO, CD3ε, CD56, granzyme B, TIA‐1, CD7, and Epstein–Barr virus (EBV)‐encoded small RNA (EBER) by in situ hybridization, and negative for cytokeratin, chromogranin A, synaptophysin, CD4, CD5, CD8, CD20, and CD30. Based on these findings, this tumor was diagnosed as extranodal NK/T‐cell lymphoma, nasal type of the uterine cervix. Diagn. Cytopathol. 2016;44:430–433. © 2016 Wiley Periodicals, Inc. |
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| Keywords: | female genital tract uterine cervix cytology malignant lymphoma extranodal NK/T‐cell lymphoma nasal type T‐cell and natural killer (NK) cell lymphoma |
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