Cytology of low‐grade cribriform cystadenocarcinoma in salivary glands: Cytological and immunohistochemical distinctions from other salivary gland neoplasms |
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| Authors: | Yoshiki Ohta PH.D. C.T. Yuko Hirota M.D. Yohko Kohno D.D.S. Koji Kishimoto PH.D. C.T. Tomoko Norose M.D. Nobuyuki Ohike M.D. Masafumi Takimoto M.D. Akira Shiokawa M.D. Hidekazu Ota M.D. |
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| Affiliation: | 1. Department of Clinico‐Diagnostic Pathology, Showa University Fujigaoka Hospital, Kanagawa, Japan;2. Department of Clinico‐Diagnostic Pathology, Showa University Koto‐Toyosu Hospital, Tokyo, Japan;3. Division of Pathology, Department of Oral Diagnostic Sciences, Showa University School of Dentistry, Tokyo, Japan;4. Department of Pathology, Clinico‐Diagnostic Pathology, Showa University School of Medicine, Tokyo, Japan |
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| Abstract: | Low‐grade cribriform cystadenocarcinoma of the parotid gland is rare malignancy that is classified as a variant of cystadenocarcinoma. In routine cytologic slides from fine‐needle aspiration of a parotid gland, we found several pseudopapillary clusters comprising mucus‐producing cells. They included a few tumor cells having three‐dimensional nuclear atypia and slight hyperchromatism, although most of the tumor cells showed bland nuclei. Our initial cytological diagnosis was: “Indeterminate. Uncertain whether cystadenocarcinoma or cystadenoma.” The subsequent histological diagnosis was low‐grade cribriform cystadenocarcinoma. Immunohistochemical staining showed diffuse and strong reactivity for S‐100; tumor nests that were rimmed by p63+ cells, which suggests intraductal proliferation. Here, we report cytomorphological findings of this case, and discuss cytological and immunohistochemical distinctions between low‐grade cribriform cystadenocarcinoma and other salivary gland tumors, including a review of the literature. Diagn. Cytopathol. 2016;44:241–245. © 2015 Wiley Periodicals, Inc. |
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| Keywords: | low‐grade cribriform cystadenocarcinoma (LGCCC) cystadenocarcinoma parotid gland fine‐needle aspiration (FNA) cytology |
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