Cytolethal distending toxin in Escherichia coli O157:H7: spectrum of conservation, structure, and endothelial toxicity |
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| Authors: | Friedrich Alexander W Lu Shan Bielaszewska Martina Prager Rita Bruns Phillip Xu Jian-Guo Tschäpe Helmut Karch Helge |
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| Affiliation: | Institute for Hygiene, the National Consulting Laboratory on Hemolytic Uremic Syndrome, University Hospital Münster, Robert Koch Str. 41, and the IZKF Münster, 48149 Münster, Germany. |
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| Abstract: | We identified the cytolethal distending toxin V (CDT-V) gene cluster in 19 (4.9%) of 391 enterohemorrhagic Escherichia coli O157:H7. cdt-V+ strains belonged to five phage types (PTs) and were most frequent within PTs 14 and 34. CDT-V was expressed in all but two cdt-V+ strains and was lethal to cultured endothelial cells. Subtyping schemes should include cdt-V as a marker to differentiate E. coli O157:H7 even within the same phage type. |
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