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| Pokemon、Ki-67蛋白在胃癌中的表达和临床意义 | |
| 引用本文： | 韩晓峰,李月锋,曲宏岩. Pokemon、Ki-67蛋白在胃癌中的表达和临床意义[J]. 实用肿瘤学杂志, 2011, 25(3): 219-222. DOI: 10.3969/j.issn.1002-3070.2011.03.005 |
| 作者姓名： | 韩晓峰 李月锋 曲宏岩 |
| 作者单位： | 哈尔滨医科大学附属第三医院胃肠外科(哈尔滨 150081) |
| 基金项目： | 黑龙江省哈尔滨市科技创新人才研究专项资金项目 |
| 摘 要： | 目的 探讨Pokemon、Ki-67蛋白在胃正常黏膜与胃癌组织中的表达及其意义。方法 应用RT-PCR法检测25例胃正常黏膜及125例胃癌组织中Pokemon、Ki-67蛋白的表达,并联系临床病理学指标进行相关分析。结果 在正常胃黏膜中Pokemon和Ki-67不表达或弱表达,在胃癌组织中表达增高,并与TNM分期及有无淋巴转移有关,与年龄、性别、肿瘤大小无关。结论 Pokemon、Ki-67蛋白的表达与胃癌的发生、发展和转移密切相关,可能共同参与了胃癌的发生、发展。Pokemon有望成为胃癌治疗的一个有效靶基因,从而为胃癌基因治疗开辟新的途径。 |
| 关 键 词： | 胃癌 Pokemon基因 原癌基因 RT—PCR Ki-67 |
| 收稿时间： | 2011-01-17 |
Expression and clinical significance of Pokemon and Ki-67 proteins in gastric cancer |
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| HAN Xiaofeng,LI Yuefeng,QU Hongyan. Expression and clinical significance of Pokemon and Ki-67 proteins in gastric cancer[J]. Journal of Practical Oncology, 2011, 25(3): 219-222. DOI: 10.3969/j.issn.1002-3070.2011.03.005 | |
| Authors: | HAN Xiaofeng LI Yuefeng QU Hongyan |
| Affiliation: | Department of Gastrointestinal Surgery,The Third Affiliated Hospital of Harbin Medical University,Harbin 150081 |
| Abstract: | Objective To study the expression of Pokemon,Ki -67 and its clinical significance in gastric cancer and normal gastric mucosa. Methods The Pokemon and Ki- 67 in gastric cancer（ n = 125 ）, normal gastric mucosa（n = 25 ）was detected by RT - PCR. Results Pokemon protein expression was high in gastric cancer group,which was significantly different from the expression in normal gastric mucosa. It was highly expressed in gastric cancer and was related with stage of TNM and lymph node metastasis, but were not related with the age,sex and the size of tumor. Conclusion Pokemon and Ki - 67 protein expression may be correlate with the carcinogenesis and genesis, development and metastasis of gastric cancer. Pokemon may be an effective target gene for therapy of gastric cancer, accordingly,which may develop a new way of gene therapy for gastric cancer. |
| Keywords: | RT-PCR Ki-67 |
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