Clinical Observation on Shuanghuanglian powder in treating viral myocarditis of childrenin treating viral myocarditis of children |
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| Authors: | Guozhen Lin Dongmei Liu Lin Zhu Dingzhong Qiu |
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| Affiliation: | (1) Affiliated Ruijin Hospital of Shanghai Second Medical University, (200025) Shanghai |
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| Abstract: | Objective: To study immune function of children viral myocarditis and to evaluate the clinical effect of Shuanghuanglian Powder (SHLP) by injection.Methods: The 62 patients of viral myocarditis were divided into two groups randomly, the SHLP group (n = 32) treated with conventional therapy plus SHLP and the conventional treatment group (n = 30) with conventional therapy alone. Their serum antibody of Coxsackie virus group B (COXB-IgM), T-lymphocyte subsets including CD3 +, CD4 +, CD8 + and CD4 +/CD8 + were determined with ELISA and indirect immunofluorescent assay.Results: COXB-IgM was positive in 39 of the 62 patients, which was significantly different with those of normal controls (P< 0.001). Patients’ serum level of CD4 + cells and CD4 +/CD8 + ratio decreased while CD8 + increased. After treatment, the recovery of symptoms, signs and immune function in patients of the SHLP group were significantly better than those in patients treated with conventional treatment alone (P<0.01).Conclusion: Immunoregulatory disturbance is involved in children with viral myocarditis and SHLP is an effective drug in the treatment of children viral myocarditis. |
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| Keywords: | Shuanghuanglian Powder infantile viral myocarditis T-lymphocyte subset Coxsackievirus group B antibody |
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