Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys |
| |
| Authors: | Turchi Janita Saunders Richard C Mishkin Mortimer |
| |
| Affiliation: | Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, Bethesda, MD 20892, USA. turchij@mail.nih.gov |
| |
| Abstract: | Excitotoxic lesion studies have confirmed that the rhinal cortex is essential for visual recognition ability in monkeys. To evaluate the mnemonic role of cholinergic inputs to this cortical region, we compared the visual recognition performance of monkeys given rhinal cortex infusions of a selective cholinergic immunotoxin, ME20.4-SAP, with the performance of monkeys given control infusions into this same tissue. The immunotoxin, which leads to selective cholinergic deafferentation of the infused cortex, yielded recognition deficits of the same magnitude as those produced by excitotoxic lesions of this region, providing the most direct demonstration to date that cholinergic activation of the rhinal cortex is essential for storing the representations of new visual stimuli and thereby enabling their later recognition. |
| |
| Keywords: | entorhinal cortex medial temporal lobe perirhinal cortex visual memory non-human primate |
| 本文献已被 PubMed 等数据库收录！ |
|
