| 复方阿苯达唑驱除肠道线虫的现场观察 |
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| 引用本文： | 张德洪,张孝蓉,唐中玖,陈闯,陈亚伟,杨文锦,靳明安,黄成芳,杨光健,龙运坤,. 复方阿苯达唑驱除肠道线虫的现场观察[J]. 中国寄生虫学与寄生虫病杂志, 1998, 26(1): 1-5 |
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| 作者姓名： | 张德洪 张孝蓉 唐中玖 陈闯 陈亚伟 杨文锦 靳明安 黄成芳 杨光健 龙运坤 |
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| 作者单位： | 四川省寄生虫病防治研究所，成都亨达制药厂 |
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| 摘 要： | 目的：观察复方阿苯达唑（每片含阿苯达唑６７ｍｇ和噻嘧啶８３．３ｍｇ基质）的驱虫效果。方法：对成人钩虫感染者１８６４例、蛔虫感染者１５６８例和鞭虫感染者１７８５例及儿童蛲虫感染者３７３例，随机分组，比较服用单剂复方阿苯达唑３片或２片与单剂阿苯达唑４００ｍｇ或噻嘧啶３０ｍｇ（含基质１０ｍｇ）／ｋｇ的驱虫效果和副作用。结果：成人复方阿苯达唑３片和２片的虫卵阴转率，钩虫分别为６５．０％和５２．７％（Ｐ＜０．０１），蛔虫均为１００％，鞭虫分别为２６．５％和１９．２％（Ｐ＜０．０１）。３片的驱钩虫效果显著优于阿苯达唑和噻嘧啶组（Ｐ均＜０．０１）。２片的驱钩虫效果亦优于噻嘧啶（Ｐ＜０．０１），与阿苯达唑无显著性差异，但驱鞭虫效果低于阿苯达唑。２－６岁儿童服复方阿苯达唑１．５片的，蛲虫卵阴转率为１００％，显著优于噻嘧啶（Ｐ＜０．０１）。复方阿苯达唑的驱虫作用快速，副作用轻，对血象、肝肾功能和心电图无显著影响。结论：复方阿苯达唑具有阿苯达唑和噻嘧啶两药的协同作用。
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| 关 键 词： | 复方阿苯达唑 阿苯达唑 噻嘧啶 线虫 现场观察 |
FIELD TRIALS ON THE EFFICACY OF ALBENDAZOLE COMPOSITE AGAINST INTESTINAL NEMATODIASIS |
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| Zhang Dehong,Zhang Xiaorong,Tang Zhongjiu Chen Chuang,Chen Yawei,Yang Wenjin Jin Mingan,Huang Chengfang,Yang Guangjian,Long Yunkun. FIELD TRIALS ON THE EFFICACY OF ALBENDAZOLE COMPOSITE AGAINST INTESTINAL NEMATODIASIS[J]. Chinese Journal of Parasitology and Parasitic Diseases, 1998, 26(1): 1-5 |
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| Authors: | Zhang Dehong Zhang Xiaorong Tang Zhongjiu Chen Chuang Chen Yawei Yang Wenjin Jin Mingan Huang Chengfang Yang Guangjian Long Yunkun |
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| Affiliation: | Sichuan Institute of Parasitic Diseases, Chengdu 610041. |
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| Abstract: | AIM: To study the anthelmintic effect of albendazole composite (containing 67 mg of albendazole and 83 3 mg base of pyrantel pamoate per tablet). METHODS: A randomized controlled study was carried out to compare the efficacy of a single dose of 3 or 2 tablets of albendazole composite versus a single dose of 400 mg of albendazole or 10 mg base/kg of pyrantel pamoate for treatment of intestinal nematodiasis including 1 864 cases infected with hookworm, 1 568 cases infected with Ascaris, 1 785 cases infected with Tricuris trichiura and 373 children infected with Enterobius vermicularis. RESULTS: In adults, the egg negative conversion rate of a single dose of 3 or 2 tablets of albendazole composite reached 65 0% and 52 7% for hookworm infection (P<0 01), 100% and 100% for Ascaris infection, and 26 5% and 19 2% for Trichuris infection (P<0 01), respectively. There were significantly better effect against hookworm with 3 tablets of albendazole composite than that with single albendazole or pyrantel pamoate (65 0% vs. 47 6% and 38 5%, P<0 01). The effect of 2 tablets of albendazole composite against hookworm was also higher than that of single pyrantel pamoate (P<0 01) and equal to single albendazole but the anthelmintic effect against Trichuris infection was lower than that of single albendazole (19 2% vs. 26 5%). In 2-6 year old children, the effect of 1 5 tablets of albendazole composite against Enterobius vermicularis infection showed an egg negative conversion rate of 100% which was higher than that of single pyrantel pamoate (100% vs. 83 0%, P<0 01). The worm collection data showed that the worm expelling action of albendazole composite was much more rapid than that of albendazole. There were no adverse effects of albendazole composite on blood picture, liver or renal function and ECG. The side effect of both 3 and 2 tablets of albendazole composite was mild and transcient. CONCLUSION: Albendazole composite exhibits a synergistic effect of both albendazole and pyrantel pamoate. |
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| Keywords: | Albendazole composite albendazole pyrantel pamoate nematode field trial |
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