Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry |
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| Authors: | Akiko Sumi Masanori Iwase Udai Nakamura Hiroki Fujii Toshiaki Ohkuma Hitoshi Ide Tamaki Jodai‐Kitamura Yuji Komorita Masahito Yoshinari Takanari Kitazono |
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| Affiliation: | 1. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;2. Diabetes Center, Hakujyuji Hospital, Fukuoka, Japan;3. Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;4. The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia;5. Division of General Internal Medicine, School of Oral Health Science, Kyushu Dental University, Kitakyushu, Fukuoka, Japan |
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| Abstract: | Aims/Introduction A younger age at menarche is associated with obesity and type 2 diabetes in adult life. The impact of early‐onset menarche on obesity and glycemic control in type 2 diabetes has not been investigated. The present study examined the relationship between age at menarche and obesity and glycemic control in type 2 diabetes. Materials and Methods A total of 2,133 patients with type 2 diabetes aged ≥20 years were divided into groups according to age at menarche (≤11, 12, 13, 14 and ≥15 years). A retrospective cohort study examined the association of menarcheal age with adiposity and hemoglobin A1c. Results Age at menarche was inversely associated with body mass index (BMI) and abdominal circumference (P < 0.001). Each 1‐year decrease in age at menarche was associated with a 0.25‐kg/m2 and 0.6‐cm increase in BMI and abdominal circumference, respectively, using a multivariate‐adjusted model. Odds ratios for obesity and abdominal obesity significantly increased in participants with age at menarche ≤11 years after multivariable adjustments when age at menarche of 13 years was used as the reference (odds ratio 1.95, 95% CI 1.33–2.88, odds ratio 1.95, 95% CI 1.32–2.87, respectively). Younger age at menarche was significantly associated with higher hemoglobin A1c (P < 0.001); however, the association was not statistically significant after adjusting for BMI. Conclusions Age at menarche of ≤11 years was associated with obesity after adjusting for confounding factors, and poor glycemic control associated with high BMI in type 2 diabetes. Age at menarche should be considered during clinical assessments. |
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| Keywords: | Age at menarche Glycemic control Type 2 diabetes mellitus |
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