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| 单胺氧化酶A基因与暴力攻击行为关系 | |
| 引用本文： | 刘华锋, 刘娅, 刘丽丽, 陈兆杰, 李为群, 王继萍, 李波. 单胺氧化酶A基因与暴力攻击行为关系[J]. 中国公共卫生, 2009, 25(12): 1456-1457. DOI: 10.11847/zgggws2009-25-12-25 |
| 作者姓名： | 刘华锋 刘娅 刘丽丽 陈兆杰 李为群 王继萍 李波 |
| 作者单位： | 1.吉林大学公共卫生学院营养与食品卫生教研室, 长春130021;2.吉林大学中日联谊医院急诊科;3.吉林省长春市朝阳区疾病预防控制中心 |
| 基金项目： | 吉林省卫生厅重点实验室项目(项目编号：123) |
| 摘 要： | 目的 探讨单胺氧化酶A(MAOA)基因与暴力攻击行为的关联性.方法 采用聚合酶链式反应-序列特异性引物(PCR-SSP)方法,检测91名某监狱暴力犯罪服刑人员(攻击组)和101名正常对照者(对照组)MAOA基因家族中rs6323位点的基因型,并常规电泳检测基因型.应用SPSS 13.0软件分析攻击组和对照组的等位基因和基因型分布规律.结果 在MAOA基因rs6323位点攻击组、对照组GG基因型频率分别为50.5%,58.4%,TT基因型频率分别为49.5%,41.6%;攻击组、对照组G等位基因频率分别为50.5%,58.4%,T等位基因频率分别为49.5%,41.6%;基因型与等位基因在攻击组和对照组的频数分布差异均无统计学意义(P>0.05).结论 MAOA基因rs6323位点基因多态性与暴力攻击行为可能无关联,但不排除MAOA基因其他SNPs与暴力攻击行为相关联. |
| 关 键 词： | 单胺氧化酶A基因 聚合酶链式反应-序列特异性引物 暴力攻击行为 |
| 收稿时间： | 2009-06-15 |
Association between MAOA gene polymorphism and violent behavior |
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| LIU Hua-feng, LIU Ya, LIU Li-li, . Association between MAOA gene polymorphism and violent behavior[J]. Chinese Journal of Public Health, 2009, 25(12): 1456-1457. DOI: 10.11847/zgggws2009-25-12-25 | |
| Authors: | LIU Hua-feng LIU Ya LIU Li-li |
| Affiliation: | 1.Department of Nutrition and Food Hygiene, School of Public Health, Jilin University Changchun 130021, China |
| Abstract: | Objective To investigate the association between monoamine oxidase A(MAOA) gene polymorphism and violent behavior.Methods Polymerase chain reaction-sequence specific primer(PCR-SSP) was applied to detect rs6323 single nucleotide polymorphism loci of MAOA gene of in 91 prisoners with violent behavior(case group) and 101 normal prisoners(control group).The genotypes of MAOA were analyzed by gel electrophoresis.The distribution of genotypic and allelic frequencies in case and control groups was analyzed with SPSS13.0.Results GG genotype frequencies in the case and the control group were 50.5% and 58.4%.TT genotype frequencies in the case and the control groups were 49.5% and 41.6%.Gallelic frequencies in the case and the control group were 50.5% and 58.4%.Tallelic frequencies in the case and the control group were 49.5% and 41.6%.No significant difference was found in the frequencies of trs 6323 between the case and the control(P>0.05).Conclusion The variance of MAOA gene polymorphism is not associated with violen tbehavior. |
| Keywords: | MAOA gene PCR-SSP violent behavior |
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