| 华南地区788例孤独症谱系障碍儿童脑干听觉诱发电位的研究 |
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| 引用本文： | 宁书尧,陈文雄,杨思渊,李嘉铃,梁华冰,胡优秀. 华南地区788例孤独症谱系障碍儿童脑干听觉诱发电位的研究[J]. 中国儿童保健杂志, 2021, 29(7): 775-778. DOI: 10.11852/zgetbjzz2020-1812 |
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| 作者姓名： | 宁书尧 陈文雄 杨思渊 李嘉铃 梁华冰 胡优秀 |
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| 作者单位： | 广州市妇女儿童医疗中心 神经内科,广东 广州 510623 |
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| 基金项目： | 广东省科技计划项目(2016A020215019) |
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| 摘 要： | 目的 研究华南地区患孤独症谱系障碍(ASD)且听力阈值正常儿童的脑干听觉诱发电位的特征.方法 回顾性分析2013-2018年在广州市妇女儿童医疗中心确诊为ASD儿童的脑干听觉诱发电位结果.将其与年龄及性别分布相匹配(P＞0.05)的健康儿童诱发电位的听阈值、波潜伏期、波间期、Ⅰ-Ⅲ/Ⅲ-Ⅴ波间期比值及Ⅴ/Ⅰ波幅比值的异...
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| 关 键 词： | 孤独症谱系障碍 脑干听觉诱发电位 儿童 |
| 收稿时间： | 2020-10-14 |
| 修稿时间： | 2020-12-08 |
Research on the brainstem auditory evoked potential in 788 children with autism spectrum disorders in South China |
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| NING Shu-yao,CHEN Wen-xiong,YANG Si-yuan,LI Jia-ling,LIANG Hua-bing,HU You-xiu. Research on the brainstem auditory evoked potential in 788 children with autism spectrum disorders in South China[J]. Chinese Journal of Child Health Care, 2021, 29(7): 775-778. DOI: 10.11852/zgetbjzz2020-1812 |
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| Authors: | NING Shu-yao CHEN Wen-xiong YANG Si-yuan LI Jia-ling LIANG Hua-bing HU You-xiu |
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| Affiliation: | Department of Neurology,Guangzhou Women and Children's Medical Center,Guangzhou,Guangdong 510623,China |
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| Abstract: | Objective To investigate the characteristics of brainstem auditory evoked potential (BAEP) in children with autism spectrum disorder (ASD) and normal hearing threshold in South China. Methods The BAEP records of ASD children in Guangzhou Women and Children's Medical Center between 2013 and 2018 were retrospectively reviewed. Healthy controls matched by age and gender were also recruited. The thresholds,wave absolute latencies (AL),wave inter peak intervals (IPL),Ⅰ-Ⅲ/Ⅲ-Ⅴ inter peak interval ratio and Ⅴ/Ⅰ amplitude ratio of BAEP between both groups were analyzed and compared. And the BAEP data of the children would be excluded from both groups if the hearing threshold of his/her ear exceeded 30 dB nHL. Results A total of 788 ASD children and 150 healthy controls were included. BAEP data of 1 530 ears in ASD group and 300 ears in control group were included in final analysis. All participants in the two groups could differentiate into well-defined waveforms of BAEP at 90 dB nHL sound stimulation. 1) The absolute latencies of wave Ⅰ,wave Ⅲ,wave V and inter peak intervals of Ⅰ-Ⅲ of ASD children were significantly longer than those of children in control group (Z=-2.006,-3.986,-2.552,-2.405,P<0.05).2) The abnormal ratio of Ⅰ-Ⅲ/Ⅲ-Ⅴ inter peak interval of ASD group (3.14%) was significantly higher than that of the control group(P<0.001). Conclusions There are distinct changes in BAEP in ASD children,especially the abnormal prolongation of brainstem conduction time,suggesting that ASD children may have brainstem dysfunction,which may lead to the damage of related information transmission. |
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| Keywords: | autism spectrum disorder brainstem auditory evoked potential children |
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