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Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages |
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| Authors: | Rosas-Magallanes Vania Stadthagen-Gomez Gustavo Rauzier Jean Barreiro Luis B Tailleux Ludovic Boudou Frédéric Griffin Ruth Nigou Jérome Jackson Mary Gicquel Brigitte Neyrolles Olivier |
| Affiliation: | Unit of Mycobacterial Genetics, Institut Pasteur, Paris, France. |
| Abstract: | Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells. |
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