In vitro susceptibilities of zygomycetes to combinations of antimicrobial agents |
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| Authors: | Dannaoui Eric,Afeltra Javier,Meis Jacques F G M,Verweij Paul E Eurofung Network |
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| Affiliation: | Department of Medical Microbiology, University Medical Center St. Radboud, 6500 HB Nijmegen, The Netherlands. |
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| Abstract: | Combinations of antimicrobial agents were tested against 35 strains of zygomycetes. The interaction between amphotericin B and rifampin was synergistic or additive. Flucytosine alone was inactive and, upon combination with amphotericin B, synergy was not achieved. The combination of amphotericin B with terbinafine was synergistic for 20% of strains, and the interaction between terbinafine and voriconazole was synergistic for 44% of strains. Antagonism was not observed. |
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