The nonpeptide neurotensin antagonist, SR 48692, used as a tool to reveal putative neurotensin receptor subtypes. |
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| Authors: | I. Dubuc, J. Costentin, J. P. Terranova, M. C. Barnouin, P. Soubri , G. Le Fur, W. Rost ne, P. Kitabgi |
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| Affiliation: | I. Dubuc, J. Costentin, J. P. Terranova, M. C. Barnouin, P. Soubrié, G. Le Fur, W. Rostène, and P. Kitabgi |
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| Abstract: | The nonpeptide neurotensin (NT) antagonist, SR 48692, was recently shown to inhibit NT binding to the cloned rat and human NT receptor and to antagonize NT effects in a variety of in vitro and in vivo assays. Here, we show that, in contrast to its antagonistic action on NT-induced hypomotility in the rat, SR 48692 failed to antagonize NT-induced hypothermia and analgesia in the mouse and rat. We suggest that these effects might be mediated through a subtype of SR 48692-insensitive NT receptor. |
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