| 甲型副伤寒沙门菌疫苗靶标蛋白筛选技术及应用 |
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| 引用本文： | 高翔,闫梅英,阚飙. 甲型副伤寒沙门菌疫苗靶标蛋白筛选技术及应用[J]. 疾病监测, 2011, 26(7): 568-574. DOI: 10.3784/j.issn.1003-9961.2011.07.020 |
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| 作者姓名： | 高翔 闫梅英 阚飙 |
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| 作者单位： | 1.中国疾病预防控制中心传染病预防控制所 传染病预防控制国家重点实验室,北京 102206; |
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| 基金项目： | 国家科技重大专项(No.2008ZX10004-002)~~ |
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| 摘 要： | 在引起伤寒、副伤寒的病原中,甲型副伤寒沙门菌所占的比例逐渐升高。我国每年均有不同程度的地方性甲型副伤寒流行及暴发,东南亚地区甲型副伤寒流行情况日趋严重。由于现在还没有针对甲型副伤寒沙门菌的疫苗,所以具有免疫原性蛋白的筛选及减毒全菌疫苗、亚单位疫苗的研制逐渐成为热点。随着甲型副伤寒沙门菌ATCC9150全基因组序列的公布,利用基因组和蛋白质组学的方法为研究甲型副伤寒沙门菌的疫苗靶标提供了良好的基础。本文综述了疫苗靶标蛋白的识别方法以及可能用于鉴别诊断或者疫苗有效靶标的潜在甲型副伤寒沙门菌抗原蛋白。
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| 关 键 词： | 甲型副伤寒沙门菌 靶标蛋白 抗原 基因组 蛋白质组 |
| 收稿时间： | 2011-05-23 |
Technique and its application for identifying vaccine target proteins of Salmonella paratyphi A |
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| GAO Xiang,,YAN Mei-ying,KAN Biao..State Key Laboratory for Communicable Disease Control , Prevention,Institute for Communicable Disease Control , Prevention,Chinese Center for Disease Control , Prevention,Beijing ,China,.Tongzhou Center for Disease Control , prevention,Beijing. Technique and its application for identifying vaccine target proteins of Salmonella paratyphi A[J]. Disease Surveillance, 2011, 26(7): 568-574. DOI: 10.3784/j.issn.1003-9961.2011.07.020 |
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| Authors: | GAO Xiang YAN Mei-ying KAN Biao..State Key Laboratory for Communicable Disease Control Prevention Institute for Communicable Disease Control Prevention Chinese Center for Disease Control Prevention Beijing China .Tongzhou Center for Disease Control prevention Beijing |
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| Affiliation: | 1.State Key Laboratory for Communicable Disease Control and Prevention, Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;2.Tongzhou Center for Disease Control and prevention, Beijing 101100, China |
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| Abstract: | The incidence of Salmonella paratyphi A infection in human is becoming higher than other pathogens causing typhoid/paratyphoid.The outbreaks caused by endemic S.paratyphi occur every year in some regions in China and the epidemic of typhoid is more serious in Southeast Asia.However,no vaccine against S.paratyphi A is available currently.Therefore,it is important to identify the immunogenic proteins that induce the immune system to produce antibody and develop the whole bacteria attenuated vaccines as well a... |
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| Keywords: | Salmonella paratyphi A target protein antigen genome proteome |
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