| 表没食子儿茶素没食子酸酯-补骨脂脂质体的制备及体外透皮性质研究 |
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| 引用本文： | 宋娟,吕成志,王栋,丁峰,于绪东. 表没食子儿茶素没食子酸酯-补骨脂脂质体的制备及体外透皮性质研究[J]. 中国麻风皮肤病杂志, 2019, 35(6): 342-345. DOI: 10.12144/zgmfskin201906342 |
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| 作者姓名： | 宋娟 吕成志 王栋 丁峰 于绪东 |
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| 作者单位： | 大连市皮肤病医院药剂科，辽宁大连，116021 |
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| 基金项目： | 大连市中医药相关科学研究计划项目(编号:17Z1009) |
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| 摘 要： | 目的:制备表没食子儿茶素没食子酸酯-补骨脂脂质体(EGCG-PL)并检测其体外透皮性。方法:采用逆向蒸发法制备EGCG-PL,以激光粒度仪测定EGCG-PL的粒度及Zeta电位,超滤-HPLC法测定包封率,Franz 扩散装置比较EGCG-PL与EGCG-补骨脂醇溶液组(EGCG-PS)体外透皮性质的差异。结果:所制备的EGCG-PL粒径分布均匀,平均粒径为(118.1±17.0)nm,Zeta电位为-29.3 mV。EGCG-PL中EGCG、补骨脂素及异补骨脂素的包封率分别为(85.58±1.07)%、(55.49± 2.82 )%和(53.73±1.29)%。体外透皮试验结果显示,EGCG-PL中EGCG、补骨脂素及异补骨脂素24 h单位面积累积透过量及皮肤滞留量均明显高于EGCG-PS。结论: EGCG-PL制备简便、质量稳定。
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| 关 键 词： | 表没食子儿茶素没食子酸酯 补骨脂 脂质体 透皮吸收 |
Preparation of epigallocatechin-3-gallate-psoralen liposome and detection of transdermal penetration in vitro |
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| SONG Juan,LYU Chengzhi,WANG Dong,DING Feng,YU Xudong. Preparation of epigallocatechin-3-gallate-psoralen liposome and detection of transdermal penetration in vitro[J]. China Journal of Leprosy and Skin Diseases, 2019, 35(6): 342-345. DOI: 10.12144/zgmfskin201906342 |
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| Authors: | SONG Juan LYU Chengzhi WANG Dong DING Feng YU Xudong |
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| Affiliation: | Department of Pharmacy, Dalian Dermatosis Hospital, Dalian 116021,China |
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| Abstract: | Objective: To prepare the epigallocatechin-3-gallate-psoralen liposome (EGCG-PL) and to detect the transdermal diffusion characteristics in vitro. Methods: EGCG-PL was prepared by reverse phase evaporation approach. The particle size, zeta potential and encapsulation efficiency of EGCG-PL were measured by laser scattering particle size distribution analyzer and ultrafiltration-HPLC method. The percutaneous diffusion characteristics of the EGCG-PL and EGCG-PS in vitro was compared by Franz diffuser device. Results: The EGCG-PL had an average size of (118.1±17.0) nm with surface charge of -29.3 mV. The encapsulation efficiency of EGCG, psoralen and isopsoralen in EGCG-PL was (85.58±1.07)%, (55.49±2.82)% and (53.73±1.29)%, respectively. The transdermal penetration study showed that the cumulative penetration amounts and drug retention amounts of the EGCG-PL were significant higher than that in EGCG-PS. Conclusion: The preparation technology of EGCG-PL is simple and the quality is stable. |
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| Keywords: | epigallocatechin-3-gallate psoralen liposome percutaneous absorption |
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