Planum temporale asymmetry in developmental dyslexia: Revisiting an old question |
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| Authors: | Irene Altarelli François Leroy Karla Monzalvo Joel Fluss Catherine Billard Ghislaine Dehaene‐Lambertz Albert M. Galaburda Franck Ramus |
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| Affiliation: | 1. Laboratoire de Sciences Cognitives et Psycholinguistique, Département d'Etudes Cognitives, Ecole Normale Supérieure, EHESS, CNRS, PSL Research University, Paris Cedex 05, France;2. Brain and Learning Laboratory, FPSE, University of Geneva, Geneva 4, Switzerland;3. INSERM, U992, Cognitive neuroimaging unit, Gif‐sur‐Yvette, France;4. Commissariat à l'Energie Atomique, Division of Life Sciences, Institute of BioImaging, Neurospin, Gif‐sur‐Yvette, France;5. Paris‐Sud University, Orsay, France;6. Assistance Publique‐H?pitaux de Paris, Le Kremlin‐Bicêtre, Paris, France;7. Neurologie pédiatrique, H?pitaux Universitaires Genève, Geneva, Switzerland;8. Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts |
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| Abstract: | Among the various asymmetrical structures of the human brain, the planum temporale, an anatomical region associated with a variety of auditory and language‐related processes, has received particular attention. While its surface area has been shown to be greater in the left hemisphere compared to the right in about two‐thirds of the general population, altered patterns of asymmetry were revealed by post mortem analyses in individuals with developmental dyslexia. These findings have been inconsistently replicated in magnetic resonance imaging studies of this disorder. In this report, we attempt to resolve past inconsistencies by analyzing the T1‐weighted MR images of 81 children (mean age: 11 years, sd: 17 months), including 46 control (25 boys) and 35 dyslexic children (20 boys). We manually outlined Heschl's gyri, the planum temporale and the posterior rami of the Sylvian fissure on participants' brain images, using the same anatomical criteria as in post mortem studies. Results revealed an altered pattern of asymmetry of the planum temporale surface area in dyslexic boys only, with a greater proportion of rightward asymmetrical cases among dyslexic boys compared to control boys. Additionally, analyses of cortical thickness showed no asymmetry differences between groups for any of the regions of interest. Finally, a greater number of Heschl's gyrus full duplications emerged for the right hemisphere of dyslexic boys compared to controls. The present findings confirm and extend early post mortem observations. They also stress the importance of taking gender into account in studies of developmental dyslexia. Hum Brain Mapp 35:5717–5735, 2014. © 2014 Wiley Periodicals, Inc. |
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| Keywords: | developmental dyslexia planum temporale structural magnetic resonance imaging gender reading |
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