| MGMT基因与头颈肿瘤的相关研究 |
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| 引用本文： | 贾传亮,张丽净,综述,宋西成审校. MGMT基因与头颈肿瘤的相关研究[J]. 山东大学耳鼻喉眼学报, 2014, 28(3): 80-85. DOI: 10.6040/j.issn.1673-3770.0.2013.350 |
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| 作者姓名： | 贾传亮 张丽净 综述 宋西成审校 |
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| 作者单位： | 1.滨州医学院， 山东 烟台 264000; 2.青岛大学医学院附属烟台毓璜顶医院耳鼻咽喉头颈外科，山东 烟台 264000； 3.青岛大学医学院， 山东 青岛 266000 |
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| 摘 要： | O6-甲基鸟嘌呤-DNA-甲基转移酶(O6-methylguanine-DNA methyltransfe-rase, MGMT)是DNA烷化剂损伤的主要修复酶，可保护基因烷化剂损伤导致的致突变、致癌作用。MGMT的表观遗传调控是影响其表达的主要机制。表达减少与肿瘤的发生发展的密切关系与其高表达增加肿瘤烷化剂化疗的耐药性成为一个互相矛盾的问题，此基因序列的单个核苷酸位点变异亦有可能与肿瘤发病风险相关。就MGMT基因在头颈肿瘤方面的研究做了综述。
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| 关 键 词： | O6-甲基鸟嘌呤-DNA-甲基转移酶 化疗 头颈肿瘤 多态性 表观遗传学 烷化剂 |
| 收稿时间： | 2013-12-11 |
MGMT gene associated with head and neck cancer |
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| JIA Chuan-liang,ZHANG Li-jing,SONG Xi-cheng. MGMT gene associated with head and neck cancer[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2014, 28(3): 80-85. DOI: 10.6040/j.issn.1673-3770.0.2013.350 |
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| Authors: | JIA Chuan-liang ZHANG Li-jing SONG Xi-cheng |
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| Affiliation: | 1. Binzhou Medical University， Yantai 264000, Shandong, China; 2. Department of Otolaryngology ＆ Head and Neck Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University， Yantai 264000， Shandong, China; 3. Medical College of Qingdao University， Qingdao 266000， Shandong, China |
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| Abstract: | As a main repair enzyme of DNA alkyl damage， the protein O6-methylguanine-DNA methyltransferase protects genes from mutation and carcinogenicity caused by alkylating. MGMT epigenetic regulation is the principal mechanism affecting its expression. There is a mutually contradictory issue of decreased expression of MGMT closely related to tumor occurrence and development and high expression resistant to alkylating chemotherapy. Single nucleotide sequence mutation of this gene locus is possibly associated with cancer incidence risks. In this paper, MGMT gene researches of head and neck cancer were reviewed. |
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| Keywords: | Head and neck cancer Alkylating agent Epigenetics O6-methylguanine-DNA methyltransferase Chemotherapy Polymorphism |
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