| 肝素酶表达鉴别良、恶性腹水无价值 |
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| 引用本文： | 蔡永国,房殿春,杨仕明,罗元辉,陈陵,王东旭. 肝素酶表达鉴别良、恶性腹水无价值[J]. 世界华人消化杂志, 2005, 13(9): 1111-1114 |
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| 作者姓名： | 蔡永国 房殿春 杨仕明 罗元辉 陈陵 王东旭 |
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| 作者单位： | 中国人民解放军第三军医大学附属西南医院全军消化专科中心,重庆市,400038;中国人民解放军第三军医大学附属西南医院全军消化专科中心,重庆市,400038;中国人民解放军第三军医大学附属西南医院全军消化专科中心,重庆市,400038;中国人民解放军第三军医大学附属西南医院全军消化专科中心,重庆市,400038;中国人民解放军第三军医大学附属西南医院全军消化专科中心,重庆市,400038;中国人民解放军第三军医大学附属西南医院全军消化专科中心,重庆市,400038 |
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| 基金项目： | 国家自然科学基金资助项目,No．30200123~~ |
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| 摘 要： |
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| 关 键 词： | 肝素酶 腹水 鉴别诊断 |
| 修稿时间： | 2005-02-14 |
Expression of heparanase mRNA is not a good predictive marker in differential diagnosis of ascites |
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| Yong-Guo Cai,Dian-Chun Fang,Shi-Ming Yang,Yuan-Hui Luo,Ling Chen,Dong-Xu Wang. Expression of heparanase mRNA is not a good predictive marker in differential diagnosis of ascites[J]. World Chinese Journal of Digestology, 2005, 13(9): 1111-1114 |
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| Authors: | Yong-Guo Cai Dian-Chun Fang Shi-Ming Yang Yuan-Hui Luo Ling Chen Dong-Xu Wang |
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| Affiliation: | Yong-Guo Cai,Dian-Chun Fang,Shi-Ming Yang,Yuan-Hui Luo,Ling Chen,Dong-Xu Wang,Department of Gastroenterology,Southwest Hospital,the Third Military Medical University,Chongqing 400038,China Supported by National Natural Science Foundation of China,No. 30200123 |
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| Abstract: | AIM: To investigate the expression of human heparanase in the peritoneal membrane autopsy specimen and the exfoliative cells of ascites, and to assess its value in the differential diagnosis of malignant and benign ascites. METHODS: Expression of heparanase mRNA in ascites was detected by RT-PCR in forty-seven patients. Heparanase protein expression in 37 biopsies of peritoneum was detected by immunohistochemistry. RESULTS: There was no difference in the expression of heparanase mRNA between benign and malignant ascites (P>0.05). Heparanase protein was expressed not only in tumor cells, but also in activated lymphocytes, epithelioid cells, and Langhans giant cells in tuberculosis peritonitis, as well as the heterotopic endometrium and interstitial cells in endometriosis. In those 36 cases detected by immunohistochemistry, no significant difference was found between benign and malignant ascites (P>0.05). CONCLUSION: High expression of heparanase mRNA in some benign ascites may be due to the increase of inflammatoty cells in the peritoneum. Expression of heparanase mRNA in sedimentation of ascites is not a good predictive marker for the differential diagnosis of benign and malignant ascites. |
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| Keywords: | Heparanase mRNA Ascites Differential diagnosis |
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