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| 幽门螺杆菌血清分型与上消化道疾病的关系 | |
| 引用本文： | 王韶英,陈锡美,王迎昕. 幽门螺杆菌血清分型与上消化道疾病的关系[J]. 实用医学杂志, 2008, 24(22): 3869-3871 |
| 作者姓名： | 王韶英 陈锡美 王迎昕 |
| 作者单位： | 同济大学附属同济医院消化内科,上海市,200065 |
| 摘 要： | 目的 探讨幽门螺杆菌(helicobacter pylori,Hp or H.pylori)分型与消化道不同疾病的关系。方法 入选198例Hp阳性的胃镜检查患者，采用免疫印迹法进行Hp的血清学分型，并取胃窦黏膜经HE染色观察胃窦黏膜病理组织学变化。结果 198例患者中检出HpI型菌株173例(87．4％)，Ⅱ型菌株25例(12．6％)。I型较II型Hp感染者胃镜下消化性溃疡、胃癌的比例更高，P=0.012；与胃炎组比较，十二指肠球部溃疡组、胃癌组的I型感染者更高（P值分别为0.026、0.048），而与胃溃疡组无显著差别(P=0.125)。病理组织学改变I型较II型Hp感染者的结果更为严重（P=0.038）。结论 临床上消化道疾病患者Hp感染以I型菌株最为多见。Hp感染的分型诊断有助于对胃、十二指肠疾病类型及病情的判断，I型菌株感染者需要更为积极的治疗。 |
| 关 键 词： | 消化系统疾病 螺杆菌 幽门 螺杆菌感染 免疫印迹法 CagA VacA |
| 收稿时间： | 2008-04-25 |
A clinical analysis of the relationship between the types of Helicobacter priori strains and chronic upper gastrointestinal diseases |
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| WANG Shao-ying,CHEN Xi-mei,WANG Ying-xin. A clinical analysis of the relationship between the types of Helicobacter priori strains and chronic upper gastrointestinal diseases[J]. The Journal of Practical Medicine, 2008, 24(22): 3869-3871 | |
| Authors: | WANG Shao-ying CHEN Xi-mei WANG Ying-xin |
| Abstract: | 【Abstract】Objective To study the relationship of the types of Helicobacter pylori(H．pylori)strains and the severity of chronic gastroduodenal diseases．Methods One hundred and ninety eight patients with chronic upper gastrointestinal symptoms who were diagnosed as H．pylori infection by gastroscopy were enrolled in this study．H．pylori strains were serotyped by immunoblot technique．The gastric biopsy specimens of all patients were studied histologically．Results Type I H．pylori strains were confirmed in 173 cases(87.4％ )，type II strains in 25 cases(12.6％ )．In distribution，the percentages of peptic ulcers and gastric cancer in patients with type I H. pylori infection were significantly higher than in patients with type II H. pylori infection (P=0．012)．The rates of type I H. pylori in duodenal ulcer group and gastric cancer group were significantly higher than that in chronic gastritis group, respectively(P=0.026,P=0.048).There was no significant difference between gastric ulcer group and chronic gastritis group(P=0.125).Type I H. pylori strain infection can result in more severe pathohistologic changes of gastric mucosa than type II(P=0.038).Conclusion Type I strains were the leading cause of H. pylori infection.The immunoblot serotyping of H. pylori strains is helpful for evaluation of the severity of chronic upper gastrointestinal diseases. It is necessary to treat type I H. pylori infection． |
| Keywords: | CagA VacA |
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