Haploidentical hematopoietic stem cell transplantation for a case with X‐linked chronic granulomatous disease |
| |
| Authors: | Ling Zhou Lu‐Jia Dong Zhi‐Yong Gao Xin‐Jian Yu Dao‐Pei Lu |
| |
| Affiliation: | 1. The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China;2. Shanghai Dao‐Pei Hospital, Shanghai, China |
| |
| Abstract: | CGD is a rare primary immunodeficiency with high mortality rates when treated conventionally, especially for the X‐chromosome‐linked form. HSCT is the only curative therapy for CGD; however, haploidentical transplantation in CGD is rare. Here, we report a case of X‐linked CGD treated successfully by haploidentical HSCT. The patient showed a positive result with full donor chimerism, good quality of life, and the absence of recurrent infectious diseases at follow‐up (68 months). Thus, haploidentical HSCT may serve as an acceptable treatment approach for patients who have CGD, but no HLA‐matched related or unrelated donor. |
| |
| Keywords: | haploidentical myeloablative conditioning X‐linked chronic granulomatous disease |
|
|
