| 非心源性疾病患者MB型肌酸激酶活性假性升高原因分析 |
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| 引用本文： | 刘群,王敏,杨玉萍,韩玮玮,金齐力. 非心源性疾病患者MB型肌酸激酶活性假性升高原因分析[J]. 蚌埠医学院学报, 2010, 35(12): 1296-1298. DOI: 10.3969/j.issn.1000-2200.2010.12.040 |
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| 作者姓名： | 刘群 王敏 杨玉萍 韩玮玮 金齐力 |
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| 作者单位： | 蚌埠医学院第二附属医院检验科, 安徽蚌埠 233040 |
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| 摘 要： | 目的:探讨非心源性疾病患者血清中MB型肌酸激酶(CK-MB)活性假性升高的原因及其与疾病的关系。方法:对日常采用免疫抑制法检测的CK-MB活性高于正常参考值(0~25U/L)、与肌酸激酶(CK)比值>0.38的55例标本进行CK同工酶琼脂糖凝胶电泳分析;1周后重取标本检测CK-MB,并与开始的CK-MB值进行比较,结合临床诊断进行分析。结果:55例患者根据临床诊断,其中恶性肿瘤41例(肝癌16例、肺癌11例、前列腺癌7例,其他肿瘤7例),肝硬化12例,其他2例;CK-MB含量百分比均<5%,其中34例恶性肿瘤检出线粒体型肌酸激酶(m acro-CK2),23例恶性肿瘤检出BB型CK(CK-BB),16例恶性肿瘤同时检出巨CK2和CK-BB。12例肝硬化患者均检出巨CK2。前后2次CK-MB活性浓度进行比较,变化差异无统计学意义(P>0.05)。结论:血清CK-MB活性的假性升高,主要是由于血液中出现了异常升高的CK-BB或巨CK(巨CK1、巨CK2);它们的出现与肝硬化及某些恶性肿瘤密切相关。
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| 关 键 词： | 磷酸转移酶类 肌酸激酶 恶性肿瘤 肝硬化 |
| 收稿时间： | 2010-06-12 |
Analysis of the causes of false increase in serum MB form creatine kinase activity and its clinical value |
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| LIU Qun,WANG Min,YANG Yu-ping,HAN Wei-wei,JIN Qi-li. Analysis of the causes of false increase in serum MB form creatine kinase activity and its clinical value[J]. Journal of Bengbu Medical College, 2010, 35(12): 1296-1298. DOI: 10.3969/j.issn.1000-2200.2010.12.040 |
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| Authors: | LIU Qun WANG Min YANG Yu-ping HAN Wei-wei JIN Qi-li |
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| Affiliation: | Clinical Laboratory, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040, China |
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| Abstract: | Objective:To discuss the cause of false increase in serum MB form creatine kinase(CK-MB) activity in non-cardiogenic patients and its relationship to the disease.Methods:The creatine kinase isoenzyme in the routine specimen of 55 patients whose CK-MB activities were higher than the reference level(>25 U/L)and the ratio to creatine kinase(CK)were more than 0.38 were determined using agarose gel electrophoresis.One week later,the CK-MB was determined again and the results were compared with the original value... |
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| Keywords: | phosphotransferass creatine kinase malignant tumor liver cirrhosis |
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