| CD103+T细胞在银屑病皮损中的表达 |
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| 引用本文： | 郝志敏,栾超,胡煜,杨永红,刘毅,陈敏,崔盘根. CD103+T细胞在银屑病皮损中的表达[J]. 中国麻风皮肤病杂志, 2016, 32(2): 70-73 |
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| 作者姓名： | 郝志敏 栾超 胡煜 杨永红 刘毅 陈敏 崔盘根 |
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| 作者单位： | 中国医学科学院皮肤病医院，江苏省皮肤病与性病分子生物学重点实验室 南京，210042 |
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| 基金项目： | 卫生公益性行业科研专项经费项目（编号：201002016） |
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| 摘 要： | 目的：明确银屑病患者皮肤CD103+T细胞的表达及其与银屑病严重程度的关系。方法：免疫组化检测29例银屑病患者皮损和非皮损皮肤及6名健康对照皮肤中表皮及真皮CD103+T细胞的表达。计算银屑病患者PASI值。结果：CD103+T细胞主要在真皮表达。银屑病患者皮损和非皮损真皮中每个高倍视野CD103+T细胞百分率分别为（26.06%±11.72）%和（12.82±4.5）%（P<0.05）；健康人对照皮肤真皮内CD103+T细胞百分率为（7.47±1.3）%，明显低于银屑病非皮损区（P<0.05）。银屑病患者皮损中，CD103+T的表达与PASI值正相关（P<0.05）。 结论：真皮中CD103+T细胞可能与银屑病的发病及严重程度有关。
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| 关 键 词： | 银屑病 CD103+T细胞 免疫组化 |
Expression of CD103+ T cells in psoriatic lesions |
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| HAO Zhimin,LUAN Chao,HU Xu,YANG Yonghong,LIU Yi,CHEN Min,CUI Pangen.. Expression of CD103+ T cells in psoriatic lesions[J]. China Journal of Leprosy and Skin Diseases, 2016, 32(2): 70-73 |
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| Authors: | HAO Zhimin LUAN Chao HU Xu YANG Yonghong LIU Yi CHEN Min CUI Pangen. |
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| Affiliation: | Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China |
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| Abstract: | Objective:To detect the level of CD103+ T lymphocytes in psoriatic lesions and to determine the relationship with the severity of psoriasis. Methods:CD103+T lymphocytes in dermis and epidermis of the lesions and non-lesional skin from 29 patients with psoriasis and skin from 6 healthy controls were detected by immunohistochemical staining. Results:CD103+ T lymphocytes mainly distributed in dermis. The mean per-centage of CD103+ T lymphocytes in lesions, non-lesional skin and normal skin was (26.06±11.72)%, (12.82±4.50)% and (7.47±1.30)% and there were significant differences among the groups (P<0.05). There was a positive correlation between the level of CD103+ T lymphocytes and the PASI score (P<0.05). Conclusion:CD103+ T lymphocytes in the dermis may associate with the occurrence and severity of psoriasis. |
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| Keywords: | psoriasis CD103+ T lymphocytes immunohistochemical staining |
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