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Predisposition to spina bifida: Search for a relation to maternal gastric acid secretion. |
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| Authors: | P A Stanway I M Samloff C J Brace J H Renwick |
| Abstract: | The peak acid output of the stomach in a group of 71 mothers of spina bifida children and in 71 matched controls was estimated indirectly by the serum level of group I pepsinogens. The mean levels did not differ significantly, suggesting that the conjectured teratogen is not specially acid-labile. The variance was significantly higher in index subjects than in controls, but the interpretation of this finding is not clear. |
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