Ribosomal alterations contribute to bacterial resistance against the dipeptide antibiotic TAN 1057 |
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| Authors: | Limburg E Gahlmann R Kroll H-P Beyer D |
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| Affiliation: | Department of Antiinfectives, Pharma Research, Bayer Health Care AG, D-42096 Wuppertal, Germany. |
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| Abstract: | TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations in the ribosomes contribute to the resistance of the bacteria. |
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