| 喉鳞状细胞癌中人类错配修复蛋白2与多药耐药蛋白表达及相关性 |
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| 引用本文： | 付琼,刘娟,吴翔燕. 喉鳞状细胞癌中人类错配修复蛋白2与多药耐药蛋白表达及相关性[J]. 中国耳鼻咽喉头颈外科, 2013, 20(9): 455-458 |
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| 作者姓名： | 付琼 刘娟 吴翔燕 |
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| 作者单位： | 杭州市萧山区第一人民医院病理科 |
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| 摘 要： | 目的研究人类错配修复蛋白2（human muts homolog 2,hMSH2）在喉鳞状细胞癌（简称喉鳞癌）中的表达及与多药耐药基因蛋白P-糖蛋白（P-glycoprotein,P-gp）表达的相关性,两者表达与临床病理特征的关系。方法采用免疫组化En-ViSion法检测喉鳞癌及声带息肉组织中hMSH2和P-gp的表达情况,同时检测hMSH2阳性表达和阴性表达组中P-gp的表达情况。结果 hMSH2蛋白在喉鳞癌组织中阳性表达率为59%,明显低于声带息肉90%（χ2=12.741,P〈0.05）,P-gp在喉鳞癌中阳性表达率为76%,显著高于声带息肉阳性表达率45%（χ2=13.260,P〈0.05）。hMSH2阳性的喉鳞癌中P-gp阳性率为69%,hMSH2阴性的喉鳞癌中P-gp阳性率为87%,差异有统计学意义（χ2=4.479,P〈0.05）。hMSH2表达与喉鳞癌分化程度、临床分期、淋巴结转移相关。P-gp表达与肿瘤分化程度、临床分期、淋巴结转移及T分级相关。结论 hMSH2与P-gp在喉鳞癌发生及恶性演进中起一定作用,hMSH2可能通过影响P-gp表达导致喉鳞癌多药耐药的产生。
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| 关 键 词： | 喉肿瘤 肿瘤，鳞状细胞 人类错配修复基因2 P-糖蛋白 |
| 收稿时间： | 2013-03-13 |
Expression of hMSH2 protein and multidrug resistance protein in laryngeal squamous cell carcinoma |
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| FU Qiong;LIU Juan;WU Xiangyan. Expression of hMSH2 protein and multidrug resistance protein in laryngeal squamous cell carcinoma[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2013, 20(9): 455-458 |
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| Authors: | FU Qiong LIU Juan WU Xiangyan |
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| Affiliation: | FU Qiong;LIU Juan;WU Xiangyan;Department of Pathology,the First People＇s Hospital of Xiaoshan;Department of Pathology,the Second Hospital of Hangzhou; |
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| Abstract: | OBJECTIVE To investigate the expression and relationship of mismatch repair protein hMSH2 and multidrug resistance protein P-gp in laryngeal squamous cell carcinoma（LSCC）,and analyze their correlation with the clinical pathologic features.METHODS Immunohistochemical En-ViSion method was used to measure the expression of hMSH2 and P-gp in 110 specimens of LSCC and 40 specimens of vocal cord polyps.RESULTS The positive expression rate of hMSH2 in LSCC（59%）was significant lower than that in vocal cord polyps（90%,χ2=12.741,P0.05）.The positive rate of P-gp in LSCC and benign lesions were 76% and 45%,respectively.The difference had statistical signifcance（χ2=13.260,P0.05）.The positive rate of P-gp in hMSH2 positive group was 69%,and in hMSH2 negative group was 87%,with significant difference（χ2=4.479,P 0.05）.The expression of hMSH2 was related to pathological grade,clinical stage and lymph node metastasis（all P0.05）.The positive expression of P-gp was correlated with pathological grade,clinical stage,lymph node metastasis and T stage（all P0.05）.CONCLUSION Abnormal expression of hMSH2 and P-gp may play a role in the development and progression of LSCC.hMSH2 may induce multidrug resistance in LSCC by infuencing expression of P-gp. |
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| Keywords: | Laryngeal Neoplasms Neoplasms Squamous Cell hMSH2 P-glycoprotein |
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