| 外泌体作为药物递送载体的研究进展 |
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| 引用本文： | 居怡, SERAG Amani Hamood Ali, 施戈韬, 高博. 外泌体作为药物递送载体的研究进展[J]. 药学进展, 2023, 47(11): 804-816. DOI: 10.20053/j.issn1001-5094.2023.11.002 |
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| 作者姓名： | 居怡 SERAG Amani Hamood Ali 施戈韬 高博 |
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| 作者单位： | 1.上海宇玫博生物科技有限公司, 上海 201318 |
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| 摘 要： | 外泌体是一种由细胞主动分泌的纳米级脂质双层囊泡，其腔内或脂质双分子层中包裹着蛋白质、脂质和核酸等多种生物成分。外泌体具有低免疫原性、高物理化学稳定性、高组织穿透能力，以及先天的运输能力，因此有望成为一类新型的药物递送载体。目前，外泌体作为药物递送载体的研究已取得了可喜的进展，有关外泌体分离以及提高其药物负载和递送效率的新方法不断涌现。然而，仍有许多困难制约了外泌体的临床应用。综述了外泌体作为药物递送载体的研究进展，对外泌体大规模生产和纯化中的技术难点进行了分析，并总结了外泌体用于药物递送的法规问题。
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| 关 键 词： | 外泌体 药物递送载体 临床试验 规模化生产 |
| 收稿时间： | 2023-09-08 |
Research Progress of Exosomes as Drug Delivery Carriers |
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| JU Yi, SERAG Amani Hamood Ali, SHI Getao, GAO Bo. Research Progress of Exosomes as Drug Delivery Carriers[J]. Progress in Pharmaceutical Sciences, 2023, 47(11): 804-816. DOI: 10.20053/j.issn1001-5094.2023.11.002 |
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| Authors: | JU Yi SERAG Amani Hamood Ali SHI Getao GAO Bo |
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| Affiliation: | 1.Umibio (Shanghai) Co. Ltd., Shanghai 201318, China |
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| Abstract: | Exosomes are nanoscale lipid bilayer vesicles actively secreted by cells.Different biological components such as proteins, lipids and nucleic acids are encapsulated in the cavity or lipid bilayer of exosomes.Exosomes exhibit low immunogenicity, high physicochemical stability, high tissue penetration ability, and innate transport ability, so they are expected to become a new class of drug delivery carriers.The research on exosomes as drug delivery carriers has seen significant progress.The novel methods for isolating exosomes and improving their drug loading and delivery efficiency are constantly emerging.However, there are still many difficulties restricting the clinical application of exosomes.This article reviews the research progress of exosomes as drug delivery carriers, analyzes the technical difficulties in the large-scale production and purification of exosomes, and summarizes the regulatory concerns for the use of exosomes in drug delivery. |
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| Keywords: | exosome drug delivery carrier clinical trial scale production |
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