| 瑞舒伐他汀对COPD稳定期患者肺功能及生活质量的影响 |
| |
| 引用本文： | 何忠建. 瑞舒伐他汀对COPD稳定期患者肺功能及生活质量的影响[J]. 蚌埠医学院学报, 2016, 41(12): 1639-1641. DOI: 10.13898/j.cnki.issn.1000-2200.2016.12.032 |
| |
| 作者姓名： | 何忠建 |
| |
| 作者单位： | 江苏省钟山干部疗养院 内科, 江苏 南京 210014 |
| |
| 摘 要： | 目的:探讨口服瑞舒伐他汀对慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）稳定期患者肺功能及生活质量的影响。方法:选取88例COPD患者，随机分为观察组和对照组，各44例。对照组患者只进行常规治疗，观察组患者在常规治疗的基础上口服瑞舒伐他汀，每次20 mg，每天1次，治疗6个月。分别在治疗前及治疗1、6个月时测定患者的第1秒用力呼气容积（FEV1）、FEV1/用力肺活量（FVC）值，评估患者的肺功能，并用CAT量表评估患者的生活质量。结果:观察组患者治疗6个月FEV1和治疗1、6个月时2组患者FEV1/FVC值均高于治疗前（P<0.01），且治疗6个月时观察组患者FEV1/FVC值明显高于对照组（P<0.01）。观察组患者治疗1、6个月时和对照组治疗6个月CAT评分均明显低于治疗前（P<0.01），且治疗1个月和6个月时观察组患者的CAT评分均明显低于对照组（P<0.01）。结论:口服瑞舒伐他汀能有效改善COPD患者的肺功能及生活质量，临床疗效显著，值得推广应用。
|
| 关 键 词： | 肺疾病，阻塞性 瑞舒伐他汀 肺功能 生活质量 |
| 收稿时间： | 2016-09-29 |
Effect of rosuvastatin on the lung function and quality of life in stable COPD patients |
| |
| Affiliation: | Department of Internal Medicine, The Cadre Sanatorium of Zhongshan, Nanjing Jiangsu 210014, China |
| |
| Abstract: | Objective:To investigate the effects of oral administration of rosuvastain on the lung function and quality of life in stable chronic obstructive pulmonary disease ( COPD) patients. Methods:Eighty-eight patients with COPD were randomly divided into the observation group and the control group ( 44 cases each group ) . The control group were treated with conventional therapy, and the observation group were treated with 20 mg rosuvastain by oral,once a day for 6 months based on conventional therapy. The first second forced expiratory volume(FEV1) and ratio of FEV1 to forced vital capacity(FVC) in patients were determined before treatment and after 1 and 6 months of treatment,which was used to evaluate the lung function of patients. The quality of life of patients was evaluated using the CAT scale. Results:The FEV1 level after 6 months of treatment,and ratio of FEV1 to FVC after 1 and 6 months of treatment in two groups were higher than higher those before treatment(P<0. 01),and the ratio of FEV1 to FVC after 6 months of treatment in observation group was higher than that in control group. The CAT score in observation group after 1 and 6 months of treatment and score of CAT in control group after 1 mouth of 6 months were lower than those before treatment(P <0. 01),and the scores of CAT in observation group affter 1 and 6 months of treatment were lower than that in control group(P<0. 01). Conclusions:The rosuvastain can improve the lung function and quality of life in patients with COPD,the curative effect of which is distinct,and worthy of popularization and application. |
| |
| Keywords: | pulmonary disease obstructive rosuvastain lung function quality of life |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《蚌埠医学院学报》浏览原始摘要信息 |
|
点击此处可从《蚌埠医学院学报》下载全文 |
