| 外周血CD4 + T淋巴细胞数量及强的松累积剂量对成人原发性肾病综合征重度感染的影响 |
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| 引用本文： | 孙良波,孟娜娜. 外周血CD4 + T淋巴细胞数量及强的松累积剂量对成人原发性肾病综合征重度感染的影响[J]. 中华实验和临床感染病杂志(电子版), 2019, 13(3): 208-213. DOI: 10.3877/cma.j.issn.1674-1358.2019.03.007 |
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| 作者姓名： | 孙良波 孟娜娜 |
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| 作者单位： | 1. 719000 榆林市，榆林市星元（第四）医院内二科2. 712000 咸阳市，陕西省核工业二一五医院肾内科 |
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| 摘 要： | 目的探讨外周血CD4+ T淋巴细胞数量及强的松累积剂量对成人原发性肾病综合征（PNS）重度感染的影响。 方法回顾性选择2012年1月至2016年12月于榆林市星元医院接受治疗的成人PNS患者120例。根据患者入院48 h后感染程度分为轻度感染组（40例）、中度感染组（52例）和重度感染组（48例）。分析不同组别患者感染部位及病原学分布，并比较不同组别PNS患者临床特征的差异。应用单因素、多因素非条件Logistic回归分析影响PNS患者重度感染的的危险因素。 结果PNS患者感染以肺部感染（72.1%）为主，肺炎克雷伯菌（10.7%）及结核分枝杆菌（12.1%）为主要病原微生物。单因素、多因素Logistic回归分析显示，强的松累积剂量（OR = 1.587、95%CI：0.144～2.687）和CD4+ T淋巴细胞计数（OR = 0.904、95%CI：0.772～0.999）可增加PNS患者重度感染风险（P均< 0.05）。 结论强的松累积剂量较大、CD4+ T淋巴细胞计数较低的患者更易发生成人PNS重度感染。
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| 关 键 词： | CD4+ T淋巴细胞 原发性肾病综合征 感染 强的松 |
| 收稿时间： | 2018-07-05 |
Effects of CD4 + T lymphocyte count and cumulative dose of prednisone in peripheral blood on severe infection of adult patients with primary nephrotic syndrome |
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| Liangbo Sun,Nana Meng. Effects of CD4 + T lymphocyte count and cumulative dose of prednisone in peripheral blood on severe infection of adult patients with primary nephrotic syndrome[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Version), 2019, 13(3): 208-213. DOI: 10.3877/cma.j.issn.1674-1358.2019.03.007 |
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| Authors: | Liangbo Sun Nana Meng |
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| Affiliation: | 1. Yulin Xingyuan (the Fourth) Hospital Internal Medicine, Yulin 719000, China2. Department of Nephrology, 215 Hospital of Nuclear Industry, Xianyang 712000, China |
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| Abstract: | ObjectiveTo investigate the effect of peripheral blood CD4+ T lymphocytes and prednisone cumulative dose on severe primary nephrotic syndrome (PNS) infection in adults. MethodsFrom January 2012 to December 2016, a total of 120 adults with PNS treated in Xingyuan Hospital of Yulin City. According to the infection degree 48 hours after admission, the patients were divided into mild infection group (40 cases), moderate infection group (52 cases) and severe infection group (48 cases). The distribution of infection sites and the pathogens in different groups were analyzed, and the differences of clinical characteristics of patients with PNS in different groups were compared. The risk factors of severe infection in patients with PNS were analyzed by single factor and multi-factor non-conditional Logistic regression analysis. ResultsThe infection of PNS was mainly caused by lung infection (72.1%); Klebsiella pneumoniae (10.7%) and Mycobacterium tuberculosis (12.1%) were main pathogenic microorganisms. Single factor, multivariate Logistic regression analysis showed that the cumulative dose of prednisone (OR = 1.587, 95%CI: 0.144-2.687) and CD4+ T lymphocyte count (OR = 0.904, 95%CI: 0.772-0.999) increased the risk of severe infection in patients with PNS (all P < 0.05). ConclusonsAdults with higher cumulative dose of prednisone and lower CD4+ T lymphocytes count were more likely to develop severe PNS infection. |
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| Keywords: | CD4+ T lymphocyte Primary nephrotic syndrome Infection Prednisone |
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