Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis |
| |
| Authors: | Marco Fischer Glenn R. Bantug Sarah Dimeloe Patrick M. Gubser Anne‐Valérie Burgener Jasmin Grählert Maria L. Balmer Leyla Develioglu Rebekah Steiner Gunhild Unterstab Ursula Sauder Gideon Hoenger Christoph Hess |
| |
| Affiliation: | 1. Department of Biomedicine, Immunobiology, University Hospital and University of Basel, Basel, Switzerland;2. Microscopy Center, Biocenter, University of Basel, Basel, Switzerland |
| |
| Abstract: | The role of mitochondrial biogenesis during naïve to effector differentiation of CD8+ T cells remains ill explored. In this study, we describe a critical role for early mitochondrial biogenesis in supporting cytokine production of nascent activated human naïve CD8+ T cells. Specifically, we found that prior to the first round of cell division activated naïve CD8+ T cells rapidly increase mitochondrial mass, mitochondrial respiration, and mitochondrial reactive oxygen species (mROS) generation, which were all inter‐linked and important for CD8+ T cell effector maturation. Inhibition of early mitochondrial biogenesis diminished mROS dependent IL‐2 production – as well as subsequent IL‐2 dependent TNF, IFN‐γ, perforin, and granzyme B production. Together, these findings point to the importance of mitochondrial biogenesis during early effector maturation of CD8+ T cells. |
| |
| Keywords: | CD8+ T cells Immunometabolism Metabolism Mitochondrial biogenesis ROS |
|
|
