Transient neonatal Cryptosporidium parvum infection triggers long-term jejunal hypersensitivity to distension in immunocompetent rats |
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| Authors: | Marion Rachel Baishanbo Asiya Gargala Gilles François Arnaud Ducrotté Philippe Duclos Celia Fioramonti Jean Ballet Jean Jacques Favennec Loïc |
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| Affiliation: | Laboratoire de Parasitologie and ADEN UPRES EA-3234, CHU Charles-Nicolle, 1, rue de Germont, 76031 Rouen, France. |
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| Abstract: | In 5-day-old immunocompetent Sprague-Dawley rats infected with either 10(2) or 10(5) Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions. |
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