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99mTc‐labeled oligomeric nanoparticles as potential agents for folate receptor‐positive tumor targeting |
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| Authors: | Lili Liang Xueqian Zhang Xiaoyu Su Jianchun Li Yong Tian Hongbao Xue Huiqin Xu |
| Affiliation: | 1. Department of Chemistry, Bengbu Medical College, Bengbu, Anhui, P. R. China;2. Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China;3. Department of Nuclear Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China;4. Faculty of Pharmacy, Bengbu Medical College, Bengbu, Anhui, P. R. China |
| Abstract: | One type of biocompatible nanoparticles functionalized with folate and 99mTc was successfully synthesized. Maleimide‐folic acid (Mal‐FA) was selected to covalently conjugate with ‐SH of the nanoparticles ( NPs ) to prepare NPs‐FA for targeting. 99mTc was selected to conjugate with ‐NH2 and ‐SH groups of cysteine residues on the surface of NPs to prepare NPs‐FA‐ 99m Tc for radioactive counting. The ability to target folate receptors of NPs‐FA‐ 99m Tc was assessed in uptake studies with folate‐receptor–positive human HepG2 cells. The results showed that the as‐prepared NPs can selectively uptake by folate receptor‐overexpressing HepG2 tumor cells in vitro. The oligomeric hybrid NPs radiolabeled with 99mTc may develop to be SPECT/CT imaging biomaterials with high selectivity. |
| Keywords: | folic acid nanomaterial radiolabeling technetium (99m) |