| 全反式维甲酸联合干扰素α-2a治疗膀胱癌 |
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| 引用本文： | 宁松毅,谈健,卜强,陆洪兵,崔飞伦,刘红耀,王东文. 全反式维甲酸联合干扰素α-2a治疗膀胱癌[J]. 肿瘤研究与临床, 2008, 20(6) |
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| 作者姓名： | 宁松毅 谈健 卜强 陆洪兵 崔飞伦 刘红耀 王东文 |
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| 作者单位： | 1. 山西医科大学第一临床医学院泌尿外科,太原,030001
2. 江苏大学附属人民医院泌尿外科 |
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| 摘 要： | 目的 观察联合应用全反式维甲酸(ATRA)和干扰素d-2a(IFN-α-2a)治疗大鼠膀胱肿瘤的疗效并探讨其机制.方法 建立大鼠膀胱肿瘤模型50只,44只存活的大鼠随机分为A(11只)、B(11只)、C(11只)、D(11只)4组,膀胱内分别灌注DMSO、IFN-α-2a、ATRA和ATRA+IFN-α-2a治疗.显微镜观察病理分期及分级,流式细胞术(FCM)检测肿瘤细胞的凋亡和细胞周期.结果 D组大鼠体重(277.4±18.5)g高于其他3组,膀胱重量(0.19±0.05)g低于其余3组,并且D组病理分期和分级均有显著降低.D组肿瘤细胞凋亡率(13.43±3.06)%较其他三组明显增加,而增生指数(19.95±4.17)%则明显降低.结论 ATRA和IFN-α-2a联合应用能显著促进肿瘤细胞凋亡,对膀胱肿瘤有更好的疗效.
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| 关 键 词： | 膀胱肿瘤 ATRA IFN-α-2a 凋亡 |
The treatment for bladder tumor with ATRA combining with interferon alpha-2a |
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| NING Song-yi,TAN Jian,BU Qiang,LU Hong-bing,CUI Fei-lun,LIU Hong-yao,WANG Dong-wen. The treatment for bladder tumor with ATRA combining with interferon alpha-2a[J]. Cancer Research and Clinic, 2008, 20(6) |
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| Authors: | NING Song-yi TAN Jian BU Qiang LU Hong-bing CUI Fei-lun LIU Hong-yao WANG Dong-wen |
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| Affiliation: | NING Song-yi[1] TAN Jian[2] BU Qiang[2] LU Hong-bing[2] CUI Fei-lun[2] LIU Hong-yao[1] WANG Dong-wen[1] |
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| Abstract: | Objective To investigate the effect of all trans-retinoic acid (ATRA) combining with Interferon α-2a on bladder tumor and the possible mechanisms. Methods Fifty female Wistar rats with bladder tumor were established and separated into 4 groups randomly that are DMSO group (A), IFN-α-2a group(B), ATRA group(C) and ATRA+IFN-α-2a group(D). Then each group was treated by drugs indicated. Finally, the weight of bladder, the stage and grade of tumor, the apoptosis and proliferation index of tumor were determined to estimate the effect of ATRA+IFN-α-2a. Results The body weights in group D are the highest and the bladder weights in group D are the lowest. The stages and grades of tumor in group D were statistically decreased compared with those in the other 3 groups. Accordingly, the apoptosis of cancer cells in group D was enhanced, whereas the proliferation index in group D was decreased significandy. Conclusion The effect of ATRA combined with Interferonα-2a on the bladder tumor is better than that of monotherapy. |
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| Keywords: | ATRA |
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