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| 2型糖尿病患者葡萄糖负荷后胰岛素分泌达峰时间的影响因素研究 | |
| 引用本文： | 廖世波,吴敏,黄淑玉,邹毅,晏益民,朱钊,黄高,李玲,向成,祝维. 2型糖尿病患者葡萄糖负荷后胰岛素分泌达峰时间的影响因素研究[J]. 中国全科医学, 2019, 22(7): 822-829. DOI: 10.12114/j.issn.1007-9572.2019.07.015 |
| 作者姓名： | 廖世波 吴敏 黄淑玉 邹毅 晏益民 朱钊 黄高 李玲 向成 祝维 |
| 作者单位： | 432000湖北省孝感市，武汉科技大学附属孝感医院内分泌科 *通信作者：黄淑玉，主任医师，硕士生导师；E-mail：957711296@qq.com |
| 摘 要： | 背景 胰岛素分泌高峰延迟在2型糖尿病（T2DM）患者中普遍存在，其可能是T2DM患者餐后高血糖的重要原因。目前国内外对T2DM患者胰岛素分泌高峰延迟影响因素的研究较少。目的 探讨T2DM患者葡萄糖负荷后胰岛素分泌达峰时间（tmax）的影响因素。方法 选取2016年1月—2018年6月于武汉科技大学附属孝感医院内分泌科住院的T2DM患者490例，根据tmax将患者分为3组：短tmax组（tmax≤90 min，n=159）、中tmax组（90 min |
| 关 键 词： | 糖尿病 2型；葡萄糖耐量试验；胰岛素释放试验；血糖；胰岛素 |
Influencing Factors of Time to Peak Insulin Level after Glucose Load in Type 2 Diabetic Patients |
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| LIAO Shibo,WU Min,HUANG Shuyu,ZOU Yi,YAN Yimin,ZHU Zhao,HUANG Gao,LI Ling,XIANG Cheng,ZHU Wei. Influencing Factors of Time to Peak Insulin Level after Glucose Load in Type 2 Diabetic Patients[J]. Chinese General Practice, 2019, 22(7): 822-829. DOI: 10.12114/j.issn.1007-9572.2019.07.015 | |
| Authors: | LIAO Shibo WU Min HUANG Shuyu ZOU Yi YAN Yimin ZHU Zhao HUANG Gao LI Ling XIANG Cheng ZHU Wei |
| Affiliation: | Department of Endocrinology，Xiaogan Hospital Affiliated to Wuhan University of Science and Technology，Xiaogan 432000，China *Corresponding author：HUANG Shuyu，Chief physician，Master supervisor；E-mail：957711296@qq.com |
| Abstract: | Background Delayed timing of peak insulin level after glucose load is common in patients with type 2 diabetes mellitus （T2DM），which may be an important cause of postprandial hyperglycemia in this population.However，there are no studies concerning the influencing factors of delayed timing of post-load peak insulin level in T2DM patients.Objective To investigate the influencing factors of time to peak insulin level after glucose load in T2DM patients.Methods We selected 490 hospitalized patients with T2DM from Department of Endocrinology，Xiaogan Hospital Affiliated to Wuhan University of Science and Technology from January 2016 to June 2018.We collected their clinical data，serum HbA1c and ketone bodies levels，routine blood test and biochemistry analysis results，FPG，blood glucose levels measured again 30，60，120，180 minutes（G30 min，G60 min，G120 min，G180 min levels） after having glucose solution in a 3-hour 75 g oral glucose tolerance test （OGTT） and fasting insulin （FINS） and INS levels measured again 30，60，120，180 minutes（I30 min，I60 min，I120 min and I180 min levels） after having glucose solution in a 3-hour insulin response test，and recorded peak INS level after glucose load （Imax） and the time during which INS was at its peak （tmax）．According to tmax，we divided them into short tmax group （tmax≤90 min，n=159），medium tmax group （90 min |
| Keywords: | Diabetes mellitus type 2；Glucose tolerance test；Insulin release test；Blood glucose；Insulin |
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