| B-flow及超声造影在类风湿关节炎手腕小关节滑膜血流显像中的应用 |
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| 引用本文： | 林增坤, 温红. B-flow及超声造影在类风湿关节炎手腕小关节滑膜血流显像中的应用[J]. 分子影像学杂志, 2018, 41(2): 142-146. doi: 10.3969/j.issn.1674-4500.2018.02.02 |
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| 作者姓名： | 林增坤 温红 |
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| 作者单位： | 惠州市中心人民医院超声医学科，广东 惠州 516001 |
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| 摘 要： | 目的探讨彩色多普勒、B-flow及超声造影在类风湿性关节炎手腕小关节滑膜血流显像的价值。方法采用GE Logiq S8 18 M马球棍形线阵探头检查240例类风湿性关节炎患者腕关节、掌指关节及近端指间关节，应用彩色多普勒检查滑膜血流信号并按Szkudlarek半定量法分为0~3级。对250个滑膜血流信号1级及以上的关节，应用频谱多普勒测量滑膜血管翳阻力指数（RI）并与半定量法作相关性分析。应用B-flow检查滑膜血流信号并与彩色多普勒比较两种技术对滑膜血流显示率的差异。对90个彩色多普勒显示滑膜无血流的类风湿性关节炎关节行超声造影，并与B-flow比较两种技术对滑膜血流检出率的差异。结果240例类风湿性关节炎滑膜均为不均匀低回声。其中200例类风湿性关节炎关节滑膜可探及血流信号（1级82例、2级72例、3级46例）。随着血流分级的增加，RI逐渐减低，血流分级与RI呈负相关。彩色多普勒与B-flow对类风湿性关节炎关节滑膜血流信号的显示率分别为154/250及206/250，差异有统计学意义（P<0.05）。90个彩色多普勒显示滑膜无血流的类风湿性关节炎关节，B-flow与超声造影的血流显示率为56/90与74/90，差异有统计学意义（P<0.05）。结论B-flow与超声造影较彩色多普勒对类风湿性关节炎关节滑膜血流显示率高，尤以超声造影明显，滑膜血管翳RI可有效评估类风湿性关节炎活动性，对类风湿性关节炎早期诊断及治疗用药，甚至治疗终点的决定有重要指导意义。
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| 关 键 词： | 类风湿关节炎 手腕小关节 滑膜 B-flow 超声造影 |
| 收稿时间： | 2018-01-16 |
Value of B-flow and contrast-enhanced ultrasonography in the imaging of synovial blood flow of small joints of wrist and hand in rheumatoid arthritis |
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| Zengkun LIN, Hong WEN. Value of B-flow and contrast-enhanced ultrasonography in the imaging of synovial blood flow of small joints of wrist and hand in rheumatoid arthritis[J]. Journal of Molecular Imaging, 2018, 41(2): 142-146. doi: 10.3969/j.issn.1674-4500.2018.02.02 |
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| Authors: | Zengkun LIN Hong WEN |
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| Affiliation: | Department of Ultrasound, Huizhou Municipal Central Hospital, Huizhou 516001, China |
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| Abstract: | ObjectiveTo explore the value of Color Doppler Flow Imaging technology (CDFI), B-flow and contrast-enhanced ultrasound (CEUS) in the blood flow imaging of synovial lesion in small joints of wrist and hand with rheumatoid arthritis (RA).MethodsA GE Logiq S8 18M polo stick-form linear array probe was used to examine the wrist joints, metacarpophalangeal joints and proximal interphalangeal joints of 240 RA patients. CDFI was applied to detect the synovial blood flow, and the result was classified into 0 ~ 3 according to Szkudlarek semi-quantitative method. For 250 cases whose synovial blood flow were over level 1, spectral doppler technology was applied to measure the resistance index (RI) of synovial pannus which was then used for the correlation analysis with the semi-quantitative method, and B-flow Ultrasound Imaging technology was used to examine the blood flow of synovium. The results of B-flow and CDFI were compared to study the difference of display rate between two devices. For 90 cases whose synovium of lesion joints had no blood signals as CDFI showed, CEUS was used and the result of which was compared with that of B-flow to study the difference of detection rate of synovial pannus.ResultsThe synovium of 240 RA samples all appeared low heterogeneous echo, among which blood flow of synovium was detected in 200 RA cases (82 of level 1, 72 of level 2, 46 of level 3). As the blood flow classification increased, RI decreased gradually; therefore, blood flow classification correlated negatively with RI. 2. The detection rates of blood flow in synovial lesion joints of RA patients displayed by CDFI and B-flows were (154/250) and (206/250), and the difference was significant (P<0.05).As for the 90 cases whose synovium of lesion joints had no blood signals as CDFI showed, the blood flow detection rates by B-flow and CEUS were (56／90) and (74／90), and the difference was significant (P<0.05).ConclusionsCompared with CDFI, B-flow and CEUS have higher detection rates of blood flow of RA synovium, especially CEUS, and they play an important role in the early diagnosis of RA and even the determination of therapeutic endpoints. RI of synovial pannus can effectively evaluate the activity of RA, and has guiding significance to clinical diagnosis, therapy and medication. |
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| Keywords: | rheumatoid arthritis small joint of wrist and hand synovium B-flow contrast-enhanced ultrasonography |
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