| 重组人生长激素对矮身材儿童身高增长疗效分析及预测模型的建立 |
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| 引用本文： | 王婷,郑荣秀,刘靓,刘朔. 重组人生长激素对矮身材儿童身高增长疗效分析及预测模型的建立[J]. 天津医科大学学报, 2018, 0(3): 232-235,244 |
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| 作者姓名： | 王婷 郑荣秀 刘靓 刘朔 |
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| 作者单位： | 天津医科大学总医院儿科，天津 300052 |
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| 摘 要： | 目的:观察重组人生长激素(rhGH)对矮身材儿童治疗效果，建立rhGH疗效预测模型,为治疗提供依据。方法:搜集因矮身材就诊的64例患儿，其中生长激素缺乏症（GHD）38例，特发性矮小症（ISS）26例，予rhGH治疗6个月，观察身高增长情况（ΔHt）、生长速率（GV）、身高差SDS（ΔHtSDS）等指标。以治疗6个月生长速率（Y）为因变量，初始胰岛素样生长因子-1值（X4），初始IGF-ISDS值（X5）、初始身高（X6）、治疗3个月身高（X10）为自变量，采用多元线性回归方法建立疗效预测模型，并前瞻性观察5例患儿，对预测模型进行验证。结果:经rhGH治疗，GHD及ISS生长均较前增快，且就ΔHt、ΔHtSDS、GV来看，前3个月治疗效果较4～6个月效果好；经rhGH治疗，GHD与ISS的治疗效果差异无统计学意义。前瞻性研究5例矮身材儿童，对模型进行验证，患儿经rhGH治疗6个月后生长速率实测值与预测值分别为（10.37±1.95）cm/年和（9.81±1.75）cm/年，二者配对t检验差异无统计学意义（P>0.05）。结论:无论是GHD还是ISS，经rhGH治疗后前3个月较4～6个月增长较快，且二者治疗效果无差异。建立的预测模型R2高，学生化残差几乎接近0，模型拟合度高，预测模型有应用价值。
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| 关 键 词： | 重组人生长激素 生长激素缺乏症 特发性矮小症 预测模型 |
Effect of recombinant human growth hormone therapy on GHD and ISS patients and establishment of prediction model |
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| WANG Ting,ZHENG Rong-xiu,LIU Liang,LIU Shuo. Effect of recombinant human growth hormone therapy on GHD and ISS patients and establishment of prediction model[J]. Journal of Tianjin Medical University, 2018, 0(3): 232-235,244 |
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| Authors: | WANG Ting ZHENG Rong-xiu LIU Liang LIU Shuo |
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| Affiliation: | Department of Pediatrics, General Hospital, Tianjin Medical University， Tianjin 300052, China |
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| Abstract: | Objective: To investigate the differences in efficacy of rhGH in treating GHD and ISS and to establish the forecast model of rhGH efficacy to guide treatment. Methods: Thirty-eight children with GHD and 26 children with ISS were enrolled in the study. Patients received rhGH treatment for at least six months. The ΔHt, GVand ΔHtSDS were observed. The effect and influencing factors of their therapy were analyzed. Then prediction models were established by multiple liner regression. Meanwhile, 5 cases were prospectively followed up for at least six months to verify the model. Results: GHD and ISS patients were taller after treatment with rhGH. In terms of ΔHt, ΔHtSDS and GV, the first three months were better than the last three months. The difference was statistically significant (P<0.05). After treatment with rhGH for 0-3 months and 4-6 months with ΔHt， ΔHtSDS and GV, the difference in therapeutic effect on GHD and ISS was not statistically significant (P> 0.05). R2=0.727. Five cases of short stature children were verified. After 6 months of rhGH treatment, the measured values and predicted values were(10.37±1.95) cm/year and （9.81±1.75） cm/year, respectively, and the difference was not statistically significant (P>0.05). Conclusion: Significant effect is obtained in the first 3 months since the treatment.RhGH therapy effect has no difference between GHD and ISS. Prediction model has application value. |
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| Keywords: | recombinant human growth hormone growth hormone deficiency idiopathic short stature prediction model |
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