| 甲状腺乳头状癌临床病理学特征与肥胖的相关性研究 |
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| 引用本文： | 彭泽椿,郑向前,高 明. 甲状腺乳头状癌临床病理学特征与肥胖的相关性研究[J]. 天津医科大学学报, 2018, 0(5): 429-432 |
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| 作者姓名： | 彭泽椿 郑向前 高 明 |
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| 作者单位： | 天津医科大学肿瘤医院甲状腺颈部肿瘤科，国家肿瘤临床医学研究中心，天津市“肿瘤防治”重点实验室，天津市恶性肿瘤临床医学研究中心，天津 300060 |
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| 摘 要： | 目的:探讨甲状腺乳头状癌临床病理学特征与体质量指数（BMI）的相关性。方法:回顾分析2015年5月-2016年7月收治行手术治疗并且术后病理回报为甲状腺乳头状癌的1 131例患者临床资料，通过单因素、多因素方法比较不同BMI指数的患者甲状腺乳头状癌的临床病理学特征。结果:单因素分析结果显示超体质量组和肥胖组较体质量正常组的性别、年龄、侵出包膜、肿瘤直径、TNM分期差异有统计学意义（P＜0.017）。多因素分析结果显示超体质量组较正常体质量组III、IV期肿瘤发生风险升高（OR=1.955，P＜0.001）。肥胖组较正常体质量组肿瘤侵出包膜风险（OR=1.951，P=0.005）和T2/3/4期比例升高（OR=2.280，P＜0.001）。结论:BMI与甲状腺乳头状癌的侵袭性有关，超体质量组的甲状腺乳头状癌III、IV期肿瘤和肥胖组肿瘤侵出包膜发生风险升高。
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| 关 键 词： | 甲状腺乳头状癌 肥胖 体质量指数 临床病理学特征 |
Correlation between body mass index and clinicopathological characteristics of papillary thyroid carcinoma |
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| PENG Ze-chun,ZHENG Xiang-qian,GAO Ming. Correlation between body mass index and clinicopathological characteristics of papillary thyroid carcinoma[J]. Journal of Tianjin Medical University, 2018, 0(5): 429-432 |
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| Authors: | PENG Ze-chun ZHENG Xiang-qian GAO Ming |
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| Affiliation: | Department of Thyroid and Neck Tumor, Cancer Institute and Hospital, Tianjin Medical University, National Clinical Research Center of Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China |
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| Abstract: | Objective: To explore the relationship between body mass index(BMI) and clinicopathological characteristics of papillary thyroid carcinoma(PTC). Methods: From May 2015 to July 2016, clinical data of 1 131 patients with PTC were retrospectively analyzed. Association between clinicopathological characteristics of PTC and BMI were assessed by univariate and multivariate analysis. Results: In our study, univariate analysis showed that the difference of factors such as sex, age, extrathyroidal extension(ETE), tumor diameter and TNM stage in overweight group and obese group had statistical significance(P <0.017). The risk for advanced stage in overweight group was increased with OR=1.955, P <0.001, compared to normal weight group. The risk for ETE and T2/3/4 stage in obese group were increased with OR=1.951, P =0.005 and OR=2.280, P <0.001, compared to normal weight group. Conclusion: BMI is associated with aggressive features of PTC. The risk for III/IV stage of the patients with PTC in overweight group and the ETE of the patients with PTC in obese group would increase. |
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| Keywords: | papillary thyroid carcinoma obesity body mass index clinicopathological characteristics |
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