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| 慢性便秘与精神心理障碍的相关性研究 | |
| 引用本文： | 樊文彬,蓝海波,谢彦鹏,杨向东. 慢性便秘与精神心理障碍的相关性研究[J]. 中国全科医学, 2019, 22(34): 4272-4276. DOI: 10.12114/j.issn.1007-9572.2019.00.456 |
| 作者姓名： | 樊文彬 蓝海波 谢彦鹏 杨向东 |
| 作者单位： | 1.610072四川省成都市，成都中医药大学附属医院 2.610031四川省成都市，四川洲际胃肠肛门病医院 3.610031四川省成都市，成都肛肠专科医院 *通信作者：杨向东，主任医师，博士生导师；E-mail：350024790@qq.com |
| 基金项目： | 四川省中医药管理局科学技术研究专项项目（2018QN021） |
| 摘 要： | 慢性便秘与精神心理障碍关系密切。便秘可继发抑郁、焦虑、睡眠障碍、躯体化障碍和强迫症、认知功能障碍等精神心理障碍。本文就两者的症状表现及发病机制相关性展开讨论。慢性便秘导致精神心理障碍的原因考虑如下：代谢产物影响，肠道微生态引起5-羟色胺、短链脂肪酸改变，下丘脑-垂体-肾上腺轴调节，应用进化论学说。特殊情况包括长期应用阿片类药物导致的慢性便秘与精神心理障碍具有相关性。通过对慢性便秘与精神心理障碍的相关性进行综述，旨在强调慢性便秘患者心理异常状态评估和治疗的必要性，为多学科-团队（MDT）诊治模式提供依据，对伴有精神心理障碍的慢性便秘的治疗思路和方法做出展望。 |
| 关 键 词： | 慢性病 便秘 情绪障碍 心理障碍 相关性 |
Correlation between Chronic Constipation and Mental Disorders |
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| FAN Wenbin,LAN Haibo,XIE Yanpeng,YANG Xiangdong. Correlation between Chronic Constipation and Mental Disorders[J]. Chinese General Practice, 2019, 22(34): 4272-4276. DOI: 10.12114/j.issn.1007-9572.2019.00.456 | |
| Authors: | FAN Wenbin LAN Haibo XIE Yanpeng YANG Xiangdong |
| Affiliation: | 1.Hospital of Chengdu University of TCM，Chengdu 610072，China 2.Sichuan Intercontinental Gastrointestinal and Anorectal Disease Hospital，Chengdu 610031，China 3.Chengdu Anorectal Hospital，Chengdu 610031，China *Corresponding author：YANG Xiangdong，Chief physician，Doctoral supervisor；E-mail：350024790@qq.com |
| Abstract: | Chronic constipation is closely related to mental disorders.Constipation can induce depression，anxiety disorders，sleep disorders，somatic disorders，obsessive-compulsive disorders，cognitive dysfunction and other mental disorders.We discussed the symptoms of chronic constipation and mental disorders，and the pathogenetic correlation between the two diseases.At present，the following reasons are considered for mental disorders caused by chronic constipation：effect of metabolites，changes of 5-hydroxytryptamine and short-chain fatty acids caused by intestinal gut microflora，regulation of the hypothalamic-pituitary-adrenal axis，and the application of the theory of evolution.Special cases include chronic constipation are associated with psychosocial disorders caused by long-term opioid application.We reviewed the correlation between chronic constipation and mental disorders，aiming to emphasize the necessity of assessment and treatment of mental disorders in chronic constipation patients，and to provide a reference for the multidisciplinary team model，and for the prospect development of treatment ideas and methods of chronic constipation with mental disorders.Chronic disease；Constipation；Mood disorders；Mental disorders；Correlation |
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