| miR-93在多囊卵巢综合征患者血清中的表达及临床意义 |
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| 引用本文： | 李英1,2,张学军1. miR-93在多囊卵巢综合征患者血清中的表达及临床意义[J]. 天津医科大学学报, 2018, 0(3): 209-211,215 |
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| 作者姓名： | 李英1 2 张学军1 |
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| 作者单位： | 1.天津医科大学免疫学系， 天津 300070；2.天津市中心妇产科医院检验科，天津 300100 |
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| 摘 要： | 目的:探讨miR-93在多囊卵巢综合征（PCOS）患者血清中的表达及临床意义。方法:利用实时荧光定量PCR分别检测PCOS患者（25例）和正常对照（25例）血清中miR-93的相对表达量，并分析miR-93与PCOS临床特征（高雄激素血症、胰岛素抵抗）的关系；绘制 ROC曲线评价血清miR-93诊断PCOS的价值。结果:与对照组相比，miR-93在PCOS患者血清中的相对表达量明显升高（Z =7.614，P < 0.01）；体质指数（BMI）、空腹血糖（FBG）、血清总睾酮（TT）和胰岛素抵抗指数（HOMA-IR）在PCOS患者中均升高（P < 0.05）。在对照组，血清miR-93的水平与TT、HOMA-IR的相关系数r值分别为0.03、0.39（均P > 0.05）；在PCOS组，血清miR-93的水平与TT、HOMA-IR的相关系数r值分别为0.33、0.28（均P > 0.05）。ROC曲线分析显示，血清miR-93用于诊断PCOS的曲线下面积为0.73，敏感度为70%，特异度为78%。结论:miR-93在PCOS患者血清中表达上调，可能与PCOS的发生发展相关，且用于诊断PCOS具有一定的价值。
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| 关 键 词： | 多囊卵巢综合征 miR-93 高雄激素血症 胰岛素抵抗 |
Expression and clinical significance of miR-93 in the serum of patients with polycystic ovary syndrome |
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| LI Ying1,' target="_blank" rel="external">2,ZHANG Xue-jun1. Expression and clinical significance of miR-93 in the serum of patients with polycystic ovary syndrome[J]. Journal of Tianjin Medical University, 2018, 0(3): 209-211,215 |
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| Authors: | LI Ying1,' target=" _blank" rel=" external" >2,ZHANG Xue-jun1 |
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| Affiliation: | 1.Department of Immunology, Tianjin Medical University, Tianjin 300070，China; 2. Department of Clinical Laboratory; Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin 300100，China |
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| Abstract: | Objective: To investigate the expression and clinical significance of serum miR-93 in patients with polycystic ovary syndrome (PCOS). Methods: The relative expression level of serum miR-93 was detected in PCOS group(n=25) and control group(n=25) by quantitative real time PCR, and the relationship between miR-93 and clinical features of PCOS (hyperandrogenemia and insulin resistance) were analyzed. Furthermore, the value of serum miR-93 was evaluated in the diagnosis of PCOS using ROC curve. Results: Compared with the control group, the relative levels of serum miR-93 in PCOS patients were significantly increased (Z =7.614, P < 0.01), and body mass index (BMI), fasting blood-glucose (FBG), serum total testosterone (TT) and insulin resistance index were elevated in PCOS patients (P < 0.05). In control group, correlation coefficient r values of serum miR-93 with TT and HOMA-IR were 0.03 and 0.39(both P > 0.05), respectively. In PCOS group, correlation coefficient r values of serum miR-93 with TT and HOMA-IR were 0.33 and 0.28 (both P > 0.05), respectively. ROC curve analysis showed that the area under the curve, sensitivity and specificity of serum miR-93 for the diagnosis of PCOS were 0.73, 70%, and 78%, respectively. Conclusion: The expression levels of miR-93 in PCOS patients are up-regulated, therefore the increment of miR-93 may be associated with the occurrence and development of PCOS, and it has certain value for the diagnosis of PCOS. |
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| Keywords: | polycystic ovary syndrome miR-93 hyperandrogenemia insulin resistance |
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