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| 制备表面图案化的聚丙烯酰胺-丙烯酸水凝胶 | |
| 引用本文： | 李淑华,李美兰. 制备表面图案化的聚丙烯酰胺-丙烯酸水凝胶[J]. 中国组织工程研究, 2020, 24(10): 1553-1556. DOI: 10.3969/j.issn.2095-4344.2230 |
| 作者姓名： | 李淑华 李美兰 |
| 作者单位： | 江苏工程职业技术学院，江苏省南通市 226007；南通大学医学院，江苏省南通市 226000 |
| 基金项目： | 江苏省先进纺织工程技术中心科研立项项目(XJFZ/2015/9)，项目参与者：李淑华~~ |
| 摘 要： | 背景:聚丙烯酰胺水凝胶具备良好的生物相容性,但力学性能较差,影响了其在生物材料领域的应用。目的:通过微模塑图形化压印制备具有特殊尺寸的聚丙烯酰胺-丙烯酸水凝胶。方法:依次将不同体积的聚丙烯酰胺溶液、丙烯酸与过硫酸铵溶液混合,加入含有微模塑图形化印章的孔板中,制备聚丙烯酰胺-丙烯酸水凝胶:A组聚丙烯酰胺溶液1.4 mL,丙烯酸0.1 mL;B组聚丙烯酰胺溶液1.3 mL,丙烯酸0.2 mL;C组聚丙烯酰胺溶液1.2 mL,丙烯酸0.3 mL;D组聚丙烯酰胺溶液1.1 mL,丙烯酸0.4 mL;E组聚丙烯酰胺溶液1.0 mL,丙烯酸0.5 mL;F组聚丙烯酰胺溶液0.9 mL,丙烯酸0.6 mL。6组过硫酸铵溶液均为50 L。光镜下观察水凝胶的图案化结构,电子万能试验机检测水凝胶的力学性能。结果与结论:光镜显示各组水凝胶表面的条纹清晰可见;丙烯酸的加入有效改良了水凝胶的力学性能,随着丙烯酸比例的不断增加,水凝胶的力学性能逐渐增强。结果表明,聚丙烯酸-丙烯酰胺水凝胶具有良好的力学性能,有望在组织工程损伤修复领域具有良好的应用前景。 |
| 关 键 词： | 表面图案化 聚丙烯酰胺 丙烯酸 水凝胶 力学性能 组织工程 生物材料 制备 |
| 收稿时间： | 2019-05-13 |
Preparation of the surface patterned polyacrylamide-acrylic hydrogel |
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| Li Shuhua,Li Meilan. Preparation of the surface patterned polyacrylamide-acrylic hydrogel[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(10): 1553-1556. DOI: 10.3969/j.issn.2095-4344.2230 | |
| Authors: | Li Shuhua Li Meilan |
| Affiliation: | JiangsuEngineering College, Nantong 226007, Jiangsu Province, China; MedicalCollege of Nantong University, Nantong 226000, Jiangsu Province, China |
| Abstract: | BACKGROUND:Polyacrylamide hydrogels have good biocompatibility,but their mechanical properties are poor,which affect their application in the field of biomaterials.OBJECTIVE:To prepare the polyacrylamide-acrylic hydrogels with a particular size by micromolding graphical imprinting.METHODS:Polyacrylamide-acrylic hydrogel was prepared by sequentially mixing different volumes of polyacrylamide solution,acrylic acid and ammonium persulfate solution into an orifice plate containing a micromolded patterned seal.Group A:polyacrylamide solution 1.4 mL,acrylic acid 0.1 mL;group B:polyacrylamide solution 1.3 mL,acrylic acid 0.2 mL;group C:polyacrylamide solution 1.2 mL,acrylic acid 0.3 mL;group D:polyacrylamide solution 1.1 mL,acrylic acid 0.4 mL;group E:polyacrylamide solution 1.0 mL,acrylic acid 0.5 mL;group F:polyacrylamide solution 0.9 mL,acrylic acid 0.6 mL.Six groups of ammonium persulfate solution were all 50μL.The patterned structure of the hydrogel was observed under a light microscope.The mechanical properties of the hydrogel were examined by an electronic universal testing machine.RESULTS AND CONCLUSION:Light microscope showed that the stripes on the surface of each group of hydrogels were clearly visible.The addition of acrylic acid effectively improved the mechanical properties of hydrogels.As the proportion of acrylic acid increased,the mechanical properties of hydrogels gradually increased.These results suggest that polyacrylic acid/acrylamide hydrogel has good mechanical properties and is expected to have good application prospects in the field of tissue engineering damage repair. |
| Keywords: | surface patterned polyacrylamide acrylic acid hydrogel mechanical property tissue engineering biomaterials preparation |
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