Risk factors of acute cerebral infarction in H type hypertensive patients in Tongchuan City
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摘要: 目的:调查铜川市H型高血压病患者急性脑梗死发生的危险因素。方法： 铜川市H型高血压病发生急性脑梗死确诊病例561例，进行1∶1配对进行病例对照研究，获得环境暴露等资料，采用EPI-info（6.04）和SPSS（15.0）统计软件进行单因素和多因素Logistic回归分析，计算各因素的调整比值比（OR）和95%可信限（CI）。结果： 单因素分析发现， H型高血压病的561例患者并发高脂血症、糖尿病、高C-反应蛋白血症、短暂性脑缺血发作（TIA）、肥胖、吸烟、酗酒等危险因素与急性脑梗死成正相关，差异有统计学意义（均P<0.05）。而马来酸依那普利叶酸片能降低H型高血压病患者患脑梗死的风险。多因素分析结果显示，糖尿病、高C-反应蛋白血症、重度颈动脉狭窄、TIA是H型高血压病发生急性脑梗死的主要危险因素，差异有统计学意义（均P<0.05）。结论： 铜川市H型高血压病患者急性脑梗死的独立危险因素是高C-反应蛋白血症、糖尿病、重度颈动脉狭窄、TIA，马来酸依那普利叶酸片是其保护因素。
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关键词:
- 高血压，原发性，H型 /
- 脑梗死，急性 /
- 危险因素 /
- 病例对照研究
Abstract: AIM:To investigate the risk factors of acute cerebral infarction in type H hypertensive patients in Tongchuan City. METHODS: A 1∶1 matched case-control study was conducted in 561 cases of confirmed acute cerebral infarction diagnosed in H type hypertensive patients in Tongchuan City. EPI-info (6.04) and SPSS (15) were used for the logistic regression analysis of single and multiple factors, and the adjusted odds ratio of each factor (OR) and 95% confidence limit (CI) were calculated. RESULTS: Single factor analysis found that hyperlipidemia, diabetes, high C-reactive protein, transient ischemic attack (TIA), obesity, smoking and alcoholism were related to acute cerebral infarction. Enalapril maleate and folic acid tablets reduced the risk of acute cerebral infarction in H type hypertensive patients. Multivariate analysis showed that diabetes, high C-reactive protein, severe carotid stenosis and TIA were the main risks of acute cerebral infarction in H type hypertensive patients. CONCLUSION: The independent risk factors in H type hypertensive patients are high C-reactive protein, diabetes, severe carotid stenosis and TIA. Enalapril maleate and folic acid tablets are protective factors. -
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