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Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor |
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| Authors: | R L Nachman K A Hajjar R L Silverstein C A Dinarello |
| Abstract: | Human endothelial cells activated with IL-1 express a surface membrane-oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury. |
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