| 替米沙坦对自发性高血压大鼠糖代谢及血清脂联素的影响 |
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| 引用本文： | 黎小妍,麦海燕,陶 玲,张 平. 替米沙坦对自发性高血压大鼠糖代谢及血清脂联素的影响[J]. 中山大学学报(医学科学版), 2013, 34(5): 708 |
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| 作者姓名： | 黎小妍 麦海燕 陶 玲 张 平 |
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| 作者单位： | 中山大学附属第三医院药剂科,广东 广州 510630 |
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| 基金项目： | 国家自然青年科学基金(81200094);广东省医学科研基金(B2012112);广东省自然科学基金(S2012040006228);广东省教育厅学科建设专项育苗工程项目(2012LYM-0004) |
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| 摘 要： | 目的】 探讨血管紧张素II 1型受体拮抗剂替米沙坦对自发性高血压大鼠(SHR)糖代谢及血清脂联素的影响。 【方法】 实验分为4组: 对照组(WKY,n = 10);高血压组(SHR,n = 10);替米沙坦组(替米沙坦,50 mg·kg-1·d-1,n = 10),氨氯地平组(氨氯地平 10 mg·kg-1·d-1,n = 10),另外两组给予安慰剂,均为灌胃法给药,12周后处死大鼠,用生化方法测定糖代谢指标,ELISA方法测定血清脂联素含量。【结果】 四组大鼠空腹血糖之间没有明显差异(P > 0.05),高血压组大鼠空腹胰岛素水平高于对照组,替米沙坦和氨氯地平不能降低SHR空腹胰岛素水平(P > 0.05)。 OGTT结果显示,30 min和120 min后高血压组大鼠血糖水平高于对照组,替米沙坦可以明显降低SHR血糖水平(P < 0.05),而氨氯地平不能降低SHR血糖水平(P > 0.05)。高血压组大鼠血清脂联素的水平要低于对照组,替米沙坦可以明显升高SHR血清脂联素的水平 (P < 0.05),而氨氯地平没有作用(P > 0.05)。【结论】 血管紧张素Ⅱ 1型受体拮抗剂替米沙坦可以升高SHR血清脂联素水平,降低30 min,120 min餐后血糖水平。
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| 关 键 词： | 替米沙坦 脂联素 自发性高血压 糖代谢 |
| 收稿时间： | 2013-04-13 |
Effect of Telmisartan on Glycometabolism and Serum Adiponectin in Spontaneously Hypertensive Rats |
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| LI Xiao-yan,MAI Hai-yan,TAO Ling,ZHANG Ping. Effect of Telmisartan on Glycometabolism and Serum Adiponectin in Spontaneously Hypertensive Rats[J]. Journal of Sun Yatsen University(Medical Sciences), 2013, 34(5): 708 |
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| Authors: | LI Xiao-yan MAI Hai-yan TAO Ling ZHANG Ping |
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| Affiliation: | Department of Pharmacy∥The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China |
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| Abstract: | 【Objective】 The aim of the study was to evaluated the effect of telmisartan, an Angiotensin II type 1 receptor antagonist, on glycometabolism and serum adiponectin in spontaneously hypertensive rats (SHR).【Methods】 Rats were randomly assigned to four groups: control groups (WKY, n = 10); spontaneously hypertensive groups (SHR, n = 10);telmisartan groups (telmisartan, 50 mg/(kg·d), n = 10), amlodipine groups (amlodipine, 10 mg/(kg· d), n = 10), the other two groups were given placebo, the all rats were gavaged for 12 weeks. Glycometabolism were measured by biochemistry methods. Serum insulin levels were measured using radio-immunity methods. Changes of serum adiponectin were measured by ELISA. 【Result】 No significant difference of fasting blood glucose was observed in four groups (P > 0.05). Serum insulin level in SHR was higher than that of WKY groups (P < 0.05), Telmisartan and amlodipine could not reduce fasting insulin level in SHR. The result of OGTT showed that blood glucose level in SHR at 30 min or 120 min was higher than WKY groups, and telmisartan could significantly reduce blood glucose level in SHR (P < 0.05), but amlodipine was not effective (P > 0.05). Serum adiponectin level in SHR was lower than that of WKY, and telmisartan could obviously increase that in SHR (P < 0.05), but amlodopine could not increase that. 【Conclusion】 Telmisartan could ameliorate the downregulation of serum adiponectin level in SHR, and reduce blood glucose level of OGTT at 30 and 120 min in SHR. |
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| Keywords: | telmisartan adiponectin spontaneously hypertension glycometabolism |
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