| 丙型肝炎病毒感染与2型糖尿病相关性研究进展 |
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| 作者单位： | 210002 南京市 解放军第81医院全军肝病中心 |
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| 摘 要： | 丙型肝炎病毒（HCV）感染与2型糖尿病（T2DM）发生关系密切。HCV影响T2DM的机制主要有干扰胰岛素信号传导、促进肿瘤坏死因子α过度表达、影响脂质代谢和铁代谢、导致胰腺细胞损伤等。T2DM在HCV各种相关并发症的发生中扮演重要角色,T2DM可引起HCV患者肝脏脂肪变性,加重肝纤维化进展,造成抗病毒治疗失败,甚至还能促进肿瘤的发生。
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| 关 键 词： | 丙型肝炎 2型糖尿病 胰岛素抵抗 信号传导通路 |
| 收稿时间： | 2015-06-03 |
Hepatitis C virus infection and diabetes mellitus type Ⅱ occurrence |
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| Li Ping,Wang Maorong. Hepatitis C virus infection and diabetes mellitus type Ⅱ occurrence[J]. Journal of Clinical Hepatology, 2016, 19(2): 253-256. DOI: 10.3969/j.issn.1672-5069.2016.02.038 |
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| Authors: | Li Ping Wang Maorong |
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| Affiliation: | Liver Disease Center of PLA,81st Hospital,Nanjing 210002,China. |
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| Abstract: | Hepatitis C virus （HCV） infection is causally associated with diabetes mellitus type Ⅱ（T2DM）. Various mechanisms have been proposed explaining involvement of HCV infection in the process of T2DM occurrence,including the interference of insulin signaling pathway,overexpression of tumor necrosis factor-α,lipid and iron metabolism inbalance,resulting in pancreatic cell damage and so on. T2DM is one of various complications associated with HCV infection. T2DM may result in hepatic steatosis,fibrosis,failure to anti-viral treatment and hepatocellular carcinoma. In this review,we summarize some available information related to HCV infection and T2DM. |
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| Keywords: | Hepatitis C Diabetes mellitus type Ⅱ Insulin resistance Signaling pathway |
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