| 非酒精性脂肪性肝病相关慢性肾病研究进展 |
| |
| 引用本文： | 雷婷,李良平. 非酒精性脂肪性肝病相关慢性肾病研究进展[J]. 实用肝脏病杂志, 2016, 19(3): 373-376. DOI: 10.3969/j.issn.1672-5069.2016.03.033 |
| |
| 作者姓名： | 雷婷 李良平 |
| |
| 作者单位： | 637000 成都市 川北医学院研究生院（雷婷）；四川省医学科学院/四川省人民医院（雷婷，李良平） |
| |
| 摘 要： | 非酒精性脂肪性肝病是与胰岛素抵抗和遗传易感性密切相关的代谢应激性肝损伤。该病已经成为全球性的公共卫生问题之一。近几年来，有研究显示非酒精性脂肪性肝病可能与慢性肾病越来越高的患病率有关。本文将重点阐述这两个疾病的相互关系以及相关发生机制，比如胰岛素抵抗、炎症、氧化应激、高凝状态、胎球蛋白-A和脂联素等在该病发病中的作用，为更全面管理非酒精性脂肪性肝病患者和慢性肾病患者提供有用的建议。
|
| 关 键 词： | 非酒精性脂肪性肝病 慢性肾病 代谢综合征 胰岛素抵抗 |
| 收稿时间： | 2015-08-14 |
Chronic kidney disease in patients with nonalcoholic fatty liver diseases |
| |
| Lei Ting,Li Liangping. Chronic kidney disease in patients with nonalcoholic fatty liver diseases[J]. Journal of Clinical Hepatology, 2016, 19(3): 373-376. DOI: 10.3969/j.issn.1672-5069.2016.03.033 |
| |
| Authors: | Lei Ting Li Liangping |
| |
| Affiliation: | North Sichuan Medical College，Nanchong 637100，Sichuan Province，China |
| |
| Abstract: | Non-alcoholic fatty liver diseases （NAFLD） is an acquired metabolic stress-induced liver diseases associated with insulin resistance and genetic susceptibility，which has become one of the global public health problems. Accumulating evidence suggests that NAFLD may be associated with an increased prevalence and incidence of chronic kidney disease （CKD）. In this review，the evidence of NAFLD related to CKD，and the putative mechanisms by which nonalcoholic fatty liver disease contributes to kidney damage will be reviewed，and we hope it will provide guidance and recommendations for more comprehensive management of patients with nonalcoholic fatty liver disease or chronic kidney disease. |
| |
| Keywords: | Nonalcoholic fatty liver disease Chronic kidney disease Metabolic syndrome Insulin resistance |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《实用肝脏病杂志》浏览原始摘要信息 |
|
点击此处可从《实用肝脏病杂志》下载免费的PDF全文 |
