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| 电子烟尼古丁递送及药代动力学研究进展 | |
| 引用本文： | 韩熠, 巩效伟, 洪鎏, 张霞, 朱东来, 李寿波, 吴俊, 李廷华, 陈永宽. 电子烟尼古丁递送及药代动力学研究进展[J]. 中国公共卫生, 2018, 34(5): 647-651. DOI: 10.11847/zgggws1114034 |
| 作者姓名： | 韩熠 巩效伟 洪鎏 张霞 朱东来 李寿波 吴俊 李廷华 陈永宽 |
| 作者单位： | 云南中烟工业有限责任公司技术中心新型烟草制品研究所，云南 昆明 650231 |
| 基金项目： | 云南中烟科技项目（2015CP06） |
| 摘 要： |  电子烟尼古丁剂量及吸入烟气尼古丁的生理强度成为消费者、特别是卷烟烟民选择电子烟产品的重要依据，而电子烟尼古丁对人体健康的影响、合适的剂量是多少以及是否能起到卷烟替代品的作用则是卫生部门和监管机构关心的话题。  电子烟尼古丁递送及药代动力学行为研究成为获知答案和提供依据的重要手段，因此，本文梳理2010 — 2016年主流文献中关于电子烟尼古丁递送及药代动力学行为方面的研究报道，列举概括电子烟尼古丁浓度、抽吸行为和经验、电子烟产品类型、实验方法等因素对尼古丁递送量、递送效率和速率及体内代谢的影响。  |
| 关 键 词： | 电子烟 尼古丁 递送 药代动力学 代谢 |
| 收稿时间： | 2017-02-23 |
Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review |
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| Yi HAN, Xiao-wei GONG, Liu HONG, . Progress in researches on delivery and pharmacokinetics of nicotine from electronic cigarette: a review[J]. Chinese Journal of Public Health, 2018, 34(5): 647-651. DOI: 10.11847/zgggws1114034 | |
| Authors: | Yi HAN Xiao-wei GONG Liu HONG |
| Affiliation: | Institute of Non-Traditional Tobacco Product, Research and Development Center, China Tobacco Yunnan Industrial Co. Ltd., Kunming, Yunnan Province 650231, China |
| Abstract: | In recent years, the awareness and popularity of electronic cigarette (e-cigarette) have shown increasingly enhancement all over the world. Nicotine levels in e-cigarettes and inhaled aerosol are important factors for e-cigarette products choice of e-cigarette users and cigarette smokers, while nicotine health effects, suitable dosage and alternative role for cigarette are the main concerns of public health officials and regulatory decision-makers. E-cigarette nicotine delivery and pharmacokinetics researches may provide valuable information and evidences for different stakeholders. This review aims to collect mainstream literatures from 2010 to 2016 and summarizes the effects of nicotine concentration, vaping behavior and experience, e-cigarette types, experimental methods on nicotine delivery content, efficiency, rate and in vivo metabolism. |
| Keywords: | electronic cigarette nicotine delivery pharmacokinetics metabolism |
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